Skip to main content

Advertisement

SpringerLink
Log in

Fat graft myringoplasty after unsuccessful tympanic membrane repair

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

The objective of the present study was to evaluate the efficacy of fat graft myringoplasty in repairing residual or recurrent tympanic membrane perforation. A retrospective analysis was performed on 31 patients, aged 25–57 years (mean 43.3), submitted to myringoplasty revision using fat graft. Fourteen were males and 17 females. Perforation size ranged from 1 to 5 mm. Follow-up time ranged from 4 to 62 months (mean 26 months). Fat graft myringoplasty was performed under local anesthesia, using ear lobe fat in 26 patients and abdominal fat in five patients closure of tympanic membrane perforation was achieved in 87.1% of ears. No modification of the hearing level was evidenced at the statistical analysis. Fat graft myringoplasty is a safe, effective and minimally invasive procedure, suitable to repair small residual/recurrent perforations of the tympanic membrane. The angiogenic properties of the fat are ideal to overcome the poor vascular supply in the vicinity of the tympanic membrane perforation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ayache S, Braccini F, Facon F et al. (2003) Adipose graft: an original option in myringoplasty. Otol Neurotol 24:158–164

    Article  PubMed  CAS  Google Scholar 

  2. Berger G, Berger S (2002) Paediatric revision myringoplasty: outcomes and prospects. J Laryngol Otol 116:690–694

    Article  PubMed  Google Scholar 

  3. Crandall DL, Hausman GJ, Kral JG (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspective. Microcirculation 4:211–232

    Article  PubMed  CAS  Google Scholar 

  4. Deddens AE, Muntz HR, Lusk RP (1993) Adipose myringoplasty in children. Laryngoscope 103:216–219

    Article  PubMed  CAS  Google Scholar 

  5. Garcia-Olmo D, Garcia-Arranz M, Herreros D et al. (2005) A phase I clinical trial of the treatment of Crohn’s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 48:1416–1423

    Article  PubMed  Google Scholar 

  6. Gold SR, Chaffoo RA (1991) Fat myringoplasty in the guinea pig. Laryngoscope 101:1–5

    Article  PubMed  CAS  Google Scholar 

  7. Gross CW, Bassila M, Lazar RH et al. (1989) Adipose plug myringoplasty: an alternative to formal myringoplasty techniques in children. Otolaryngol Head Neck Surg 101:617–620

    PubMed  CAS  Google Scholar 

  8. Halik JL, Smith GDL (1988) Long term results of tympanic membrane repair. Otolaryngol Head Neck Surg 98:162–169

    PubMed  CAS  Google Scholar 

  9. Landsberg R, Fishman G, Derowe A et al. (2006) Fat graft myringoplasty: results of a long term follow-up. J Otolaryngol 35:44–47

    Article  PubMed  Google Scholar 

  10. Lendeckel S, Jodicke A, Christophis P et al. (2004) Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg 32:370–373

    PubMed  Google Scholar 

  11. Nishimura T, Hashimoto H, Nakanishi I et al. (2000) Microvascular angiogenesis and apoptosis in the survival of free fat grafts. Laryngoscope 110:1333–1338

    Article  PubMed  CAS  Google Scholar 

  12. Ozgursoy OB, Yorulmaz I (2005) Fat graft myringoplasty: a cost-effective but underused procedure. J Laryngol Otol 119:277–279

    Article  PubMed  CAS  Google Scholar 

  13. Palva T (1987) Surgical treatment of chronic ear disease. I. myringoplasty and tympanoplasty. Acta Otolaryngol (Stockh) 104:279–284

    CAS  Google Scholar 

  14. Palva T (1988) Surgical treatment of chronic ear disease. III. Revision after tympanomastoid surgery. Acta Otolaryngol (Stockh) 105:82–89

    CAS  Google Scholar 

  15. Reijnen CJH, Kuijpers W (1971) The healing pattern of the drum membrane. Acta Otolaryngol (Stockh) Suppl 287:1–74

    CAS  Google Scholar 

  16. Ringenberg JC (1962) Fat graft tympanoplasty. Laryngoscope 72:188–192

    Article  PubMed  CAS  Google Scholar 

  17. Sheehy JL, Anderson RG (1980) Myringoplasty: a review of 472 cases. Ann Otol Rhinol Laryngol 89:331–334

    PubMed  CAS  Google Scholar 

  18. Silverman K, Lund DP, Zetter BR et al. (1988) Angiogenic activity of adipose tissue. Biochem Biophys Res Commun 153:347–352

    Article  PubMed  CAS  Google Scholar 

  19. Vartiainen E (1992) Results of surgical treatment for chronic noncholesteatomatous otitis media in the pediatric population. Int J Pediatr Otolaryngol 24:209–216

    Article  CAS  Google Scholar 

  20. Yigit O, Alkan S, Topuz E et al. (2005) Short-term evaluation of over under myringoplasty technique. Eur Arch Otorhinolaryngol 262:400–403

    Article  PubMed  Google Scholar 

  21. Zhang QX, Magovern CJ, Mack CA et al. (1997) Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanisms of omethum-mediated angiogenesis. J Surg Res 67:147–154

    Article  PubMed  CAS  Google Scholar 

  22. Zuk PA, Zhu M, Ashjian P et al. (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279–1495

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otolaryngology, Civil Hospital “Borgo Trento”, Verona, Italy

    Francesco Fiorino & Franco Barbieri

  2. Unità Operativa di Otorinolaringoiatria, Ospedale Civile Maggiore, Azienda Ospedaliera di Verona, Piazzale Stefani, Verona, 37100, Italy

    Francesco Fiorino

Authors
  1. Francesco Fiorino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Franco Barbieri
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Francesco Fiorino.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fiorino, F., Barbieri, F. Fat graft myringoplasty after unsuccessful tympanic membrane repair. Eur Arch Otorhinolaryngol 264, 1125–1128 (2007). https://doi.org/10.1007/s00405-007-0323-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-007-0323-z

Keywords

Search

Navigation