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Experimental study of a porous rat tracheal prosthesis made of T40: long-term survival analysis

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology and Head & Neck Aims and scope Submit manuscript

Abstract

In order to repair large defects in the laryngotracheal area, we developed a biomaterial based on porous titanium (Ti40) formed of spherical particles that are welded together. These Ti40 beads were arranged in several layers to create the rat tracheal prosthesis. After a partial tracheal resection, the prosthesis was fixed to both extremities to replace the missing part. Tissue surrounding the prosthesis was collected from 33 surviving animals after an implantation period of 3 to 12 months. Histological analyses showed that the periphery of the prosthesis was covered with fibroblasts and a few lymphocytes that penetrated the titanium layers. A ciliary cylindrical epithelium of respiratory type was found on the endoluminal side. The inflammatory reaction observed was minimal. These data indicate that the prosthesis, implanted in a laryngotracheal environment, is well tolerated by animals. Our results represent the first step towards the construction of a total laryngeal prosthesis that should allow restoration of the essential functions of the larynx after a laryngectomy in cancer treatment.

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Acknowledgements

The “Ligue Contre le Cancer” supported this work. We are grateful to Dr. Anne Braun for correcting the manuscript.

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Authors and Affiliations

  1. Department of Otorhinoaryngology, CHU Hautepierre, avenue Molière, 67098, Strasbourg, France

    P. Schultz & C. Debry

  2. Department of Research, INSERM 595, Strasbourg, France

    D. Vautier & C. Egles

Authors
  1. P. Schultz
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  2. D. Vautier
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  3. C. Egles
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  4. C. Debry
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Correspondence to P. Schultz.

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Schultz, P., Vautier, D., Egles, C. et al. Experimental study of a porous rat tracheal prosthesis made of T40: long-term survival analysis. Eur Arch Otorhinolaryngol 261, 484–488 (2004). https://doi.org/10.1007/s00405-003-0717-5

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  • DOI: https://doi.org/10.1007/s00405-003-0717-5

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