Skip to main content


Log in

Metastatic renal cell carcinoma presenting as epistaxis

  • Miscellaneous
  • Published:
European Archives of Oto-Rhino-Laryngology and Head & Neck Aims and scope Submit manuscript


Metastatic tumors in the nasal and paranasal sinuses are very rare. The origin of metastatic tumors in the nasal or paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency to early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper we deal with the case of a 73-year-old patient who presented with recurrent epistaxis. The presence of a primary renal cell carcinoma was recognized only after surgical removal of the metastatic tumor. The presentation, difficulties in diagnosis and treatment of this tumor are discussed, with a review of the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others


  1. Miyamoto R, Helmus C (1973) Hypernephroma metastatic to the head and neck. Laryngoscope 83:898–905

    Google Scholar 

  2. Hefer T, Joachims HZ, Golz A (1994) Metastatic renal cell carcinoma to the nose. Eur Arch Otorhinolaryngol 251:127–129

    CAS  Google Scholar 

  3. Nahum AM, Bailey BJ (1963) Malignant tumors metastatic to the paranasal sinuses. Laryngoscope 73:942–953

    Google Scholar 

  4. Gottlieb MD, Roland JT Jr (1998) Paradoxical spread of renal cell carcinoma to the head and neck. Laryngoscope 108:1301–1305

    Google Scholar 

  5. Lockish JJ, Harrison JH (1975) Renal cell carcinoma. Natural history and chemotherapeutic experience. J Urol 115:371–374

    Google Scholar 

  6. Bernstein JM, Montgomery MD, Balogh K Jr (1966) Metastatic tumors to maxilla, nose, and paranasal sinuses. Laryngoscope 76:621–650

    Google Scholar 

  7. Xia G, Kageyama Y, Hayashi T, Kawakami S, Yoshida M, Kihara K (2001) Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma. Cancer 91:1429–1436

    CAS  PubMed  Google Scholar 

  8. Turner KJ, Moore JW, Jones A, Taylor CF, Cuthbert-Heavens D, Han C, Leek RD, Gatter KC, Maxwell PH, Ratcliffe PJ, Cranston D, Harris AL (2002) Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res 62:2957–2961

    CAS  PubMed  Google Scholar 

  9. Skinner DG, Colvin RB, Vermillion CD, Pfister RC, Leadbetter WF (1971) Diagnosis and management of renal cell carcinoma. A clinical and pathologic study of 309 cases. Cancer 28:1165–1177

    Google Scholar 

  10. Matsumoto Y, Yanagihara N (1982) Renal clear cell carcinoma metastatic to the nose and paranasal sinuses. Laryngoscope 92:1190–1193

    Google Scholar 

  11. Terada N, Hiruma K, Suzuki M, Numata T, Konno A (1998) Metastasis of renal cancer to the ethmoid sinus. Acta Otolaryngol (Stockh) [Suppl 537]:82–86

  12. Dineen MK, Pastore RD, Emrich LJ, Huben RP (1988) Results of surgical treatment of renal cell carcinoma with solitary metastasis. J Urol 140:277–279

    CAS  PubMed  Google Scholar 

Download references


This study was supported by the Brain Korea Project 21 and Korea University.

Author information

Authors and Affiliations


Corresponding author

Correspondence to H.-M. Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, HM., Kang, H.J. & Lee, S.H. Metastatic renal cell carcinoma presenting as epistaxis. Eur Arch Otorhinolaryngol 262, 69–71 (2005).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: