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Genetic analysis of a variant luteinizing hormone in an infertile woman

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Abstract 

In a woman with infertility and an endometrial polyp, we analyzed the nucleotide sequence of the β-subunit of her luteinizing hormone which showed anomalous immunogenecity in that it was recognized by time resolved-fluoroimmunoassay but not by immunoradiometric assay. The sequence analysis showed two substitutional mutations of β-subunit Trp (TGG) to Arg (CGG) and Ile (ATC) to Thr (ACC). The variant luteinizing hormone might have had some relation to the infertility and the endometrial polyp.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501 Japan e-mail: komor615@hyo-med.ac.jp Tel.: 81-798-45-6481, Fax: 81-798-46-4163, , , , , , JP

    A. Okuno, S. Komori, K. Sakata, Y. Tsuji & K. Koyama

  2. Laboratory of Developmental Biology and Medicine, Institute of Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, , , , , , JP

    Y. Nakata

  3. Ashiya Municipal Hospital, Ashiya, , , , , , JP

    T. Kameda

Authors
  1. A. Okuno
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  2. S. Komori
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  3. K. Sakata
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  4. Y. Nakata
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  5. Y. Tsuji
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  6. K. Koyama
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  7. T. Kameda
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Additional information

Received: 28 August 2000 / Accepted: 17 October 2000

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Okuno, A., Komori, S., Sakata, K. et al. Genetic analysis of a variant luteinizing hormone in an infertile woman. Arch Gynecol Obstet 265, 148–150 (2001). https://doi.org/10.1007/s004040000148

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  • DOI: https://doi.org/10.1007/s004040000148

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