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Evaluation of controlling nutritional status (CONUT) score in the prognosis of hyperemesis gravidarum

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To investigate the predictive value of the Controlling Nutritional Status (CONUT) score on hyperemesis gravidarum (HG) severity, hospitalization, and length of stay.

Materials and methods

This retrospective cross-sectional study, conducted between December 2022 and June 2023, involved two groups. Group 1 comprised 52 pregnant women diagnosed with HG in the first trimester, receiving hospitalization and treatment. Group 2 included 105 pregnant women diagnosed with HG in the first trimester, managed and treated as outpatients. The CONUT score was calculated with the formula: Serum albumin score + total lymphocyte score + total cholesterol score. This score is calculated with a number of points between 0 and 12. The interpretation of the score involves four categories: normal (0–1), light (2–4), moderate (5–8), and severe (9–12).

Results

The CONUT score differed significantly between the hospitalized (4, IQR: 2.25–5) and outpatient groups (2, IQR: 2–3) (p < 0.001). A CONUT score >3 was associated with the need for hospitalization, demonstrating a sensitivity of 60%, a specificity of 84% (p < 0.001). The CONUT score was the parameter with the highest odds ratio (OR) value among the parameters related to the need for hospitalization, and each unit increase in the CONUT score increased the need for hospitalization by 1.683 times [OR = 1.683 (95% CI: 1.042–2.718), p = 0.033]. A positive correlation was found between the CONUT score and the duration of hospital stay (r = 0.316, p = 0.023).

Conclusions

This study suggests CONUT score as a valuable tool for predicting HG severity, hospitalization need, and duration of hospital stay.

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Data availability

The data that support the findings of this study are available from the corresponding authors upon reasonable request.

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Funding

The authors received no financial support for this article’s research, authorship, and publication.

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Authors and Affiliations

  1. Division of Perinatology, Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara, Turkey

    Gulsan Karabay, Burak Bayraktar, Zeynep Seyhanli, Betul Tokgoz Cakir, Gizem Aktemur, Mevlut Bucak & Can Tekin Iskender

  2. Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara, Turkey

    Serap Topkara Sucu & Izzet Ozgurluk

Authors
  1. Gulsan Karabay
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  2. Burak Bayraktar
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  3. Zeynep Seyhanli
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Contributions

GK and BB conducted the population study, analyzed and interpreted the data, and wrote the article. ZS, STS, BTC, GA, MB participated in data analysis, interpretation, and manuscript revision. IO and CTI participated in data collection and interpretation of results. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Gulsan Karabay or Burak Bayraktar.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Ethics Committee of Ankara Etlik City Hospital (approval number: AESH-EK1-2023-276). This study was conducted in accordance with the principles of the Declaration of Helsinki on the Ethical Principles of Medical Research.

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Karabay, G., Bayraktar, B., Seyhanli, Z. et al. Evaluation of controlling nutritional status (CONUT) score in the prognosis of hyperemesis gravidarum. Arch Gynecol Obstet (2024). https://doi.org/10.1007/s00404-024-07534-x

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