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Comparison between oral dydrogesterone versus micronized vaginal progesterone gel in clinical outcome within the first HRT-FET cycle: a retrospective analysis

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The purpose of this study is to compare the clinical efficacy of oral dydrogesterone and micronized vaginal progesterone (MVP) gel during the first HRT-FET cycle.

Methods

A retrospective cohort study based on a total of 344 women undergoing their first HRT-FET cycles without Gonadotropin-Releasing Hormone agonist (GnRH-a) pretreatment was conducted. All the cycles were allocated to two groups in the reproductive medical center at the University of Hong Kong-Shenzhen Hospital. One group (n = 193) received oral dydrogesterone 30 mg/d before embryo transfer, while the other group (n = 151) received MVP gel 180 mg/d.

Results

The demographics and baseline characteristics of two groups were comparable. We found no statistically significant difference in live birth rate (24.35% vs. 31.13%, P = 0.16), clinical pregnancy rate (34.72% vs. 36.42%, P = 0.74), embryo implantation rate (25.09% vs. 28.36%, P = 0.43), positive pregnancy rate (42.49% vs 38.41%, P = 0.45), miscarriage rate (9.33% vs 3.97%, P = 0.05), or ectopic pregnancy rate (0.52% vs. 0.66%, P = 0.86) between the oral dydrogesterone group and MVP gel group. In the multivariate logistic regression analysis for covariates, medication used for luteal support was not associated with live birth rate (OR = 0.73, 95% CI: 0.32–1.57, P = 0.45). And the different luteal support medication did not have a significant positive association with the live birth rate in the cycles with day 2 embryo transferred (OR = 1.39, 95% CI:0.66–2.39, P = 0.39) and blastocyst transferred (OR = 1.31 95% CI:0.64–2.69, P = 0.46).

Conclusion

30 mg/d oral dydrogesterone and 180 mg/d MVP gel revealed similar reproductive outcomes in HRT-FET cycles in the study.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request and with permission of the corresponding author.

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Acknowledgements

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Funding

This study did not receive any specific grant from any funding agency.

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Authors and Affiliations

  1. Center of Reproductive Medicine, The University of Hong Kong-Shenzhen Hospital, No.1, Haiyuan Road, Shenzhen City, Guangdong Province, The People’s Republic of China

    Tian-Min Ye, Long-Dan Luo, Yuan-Fei Huang & Shufang Ding

  2. Center of Reproductive Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200233, China

    Tian-Min Ye

  3. Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, Guangdong Province, China

    Long-Dan Luo & Yuan-Fei Huang

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  1. Tian-Min Ye
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  2. Long-Dan Luo
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Tian-Min Ye, Long-Dan Luo, Yuan-Fei Huang and Shufang Ding. The first draft of the manuscript was written by Tian-Min Ye and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Tian-Min Ye.

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Conflict of interest

The authors have no conflicts of interest to disclose.

Ethical approval

The study was approved by the ethical committee of the University of Hong Kong-Shenzhen Hospital and the approval number was 2022–170.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

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All the patients signed the consent form before IVF treatment.

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Ye, TM., Luo, LD., Huang, YF. et al. Comparison between oral dydrogesterone versus micronized vaginal progesterone gel in clinical outcome within the first HRT-FET cycle: a retrospective analysis. Arch Gynecol Obstet 309, 2167–2173 (2024). https://doi.org/10.1007/s00404-024-07465-7

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  • DOI: https://doi.org/10.1007/s00404-024-07465-7

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