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A comparison of the effects of oral dydrogesterone and levonorgestrel-releasing intrauterine device on quality of life and sexual function in patients with abnormal uterine bleeding

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The purpose of this study is to compare the effects of cyclic oral dydrogesterone treatment and levonorgestrel-releasing intrauterine device (LNG_IUD) on quality of life (QoL) and sexual function in patients diagnosed with abnormal uterine bleeding (AUB).

Study design

The study was conducted at the University of Health Sciences Turkey Health Istanbul Kanuni Sultan Süleyman Training and Research Hospital, on 171 sexually active patients, aged 18–45, who were under a minimum of 6 months of treatment for AUB. 85 patients were treated with oral cyclic dydrogesterone, and 86 patients received LNG-IUD. Following a minimum of 6 months of treatment, these patients were recruited to the study and were asked to complete a 36-Item Short Form Survey (SF-36) and the Female Sexual Function Index (FSFI).

Results

When the FSFI scores of the patients were compared, it was observed that the total FSFI score was significantly higher in the cyclic dydrogesterone group (p < 0.05). Likewise, it was observed that sexual desire, arousal, and lubrication domains were significantly higher in the cyclic dydrogesterone group (p < 0.05). No significant differences were found between the treatment groups in 7 out of the 8 dimensions of SF-36. The energy/vitality dimension was found to be significantly higher in the cyclic dydrogesterone group.

Conclusion

Total FSFI score, as well as sexual desire, arousal, and lubrication scores, were significantly higher in the cyclic dydrogesterone group compared to the LNG-IUD group indicating that cyclic dydrogesterone has a more positive impact on sexual function when compared to LNG-IUD.

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Data availability

The dataset used for the current study is available from the corresponding author upon reasonable request.

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Acknowledgements

We thank all our study subjects for participating in this study.

Funding

None received.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University of Health Sciences Turkey, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey

    Ruken Abul & Pınar Yalçın Bahat

  2. Department of Obstetrics and Gynaecology, University of Health Sciences Turkey, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey

    Nura Fitnat Topbas Selcuki

  3. Department of Gynaecology and Obstetrics, Arnavutkoy State Hospital, Eski Edirne Street, No: 3, Arnavutkoy Centre, 34275, Istanbul, Turkey

    Ozan Karadeniz

Authors
  1. Ruken Abul
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  2. Nura Fitnat Topbas Selcuki
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  3. Ozan Karadeniz
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  4. Pınar Yalçın Bahat
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Contributions

RA: manuscript writing/editing, protocol/project development, data collection or management NFT: data collection or management, manuscript writing/editing, data analysis OK: manuscript writing/editing, data analysis PYB: protocol/project development, data analysis, manuscript writing/editing.

Corresponding author

Correspondence to Ozan Karadeniz.

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Abul, R., Selcuki, N.F.T., Karadeniz, O. et al. A comparison of the effects of oral dydrogesterone and levonorgestrel-releasing intrauterine device on quality of life and sexual function in patients with abnormal uterine bleeding. Arch Gynecol Obstet 309, 715–719 (2024). https://doi.org/10.1007/s00404-023-07315-y

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  • DOI: https://doi.org/10.1007/s00404-023-07315-y

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