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PCOS and vitamin D: a clinical appraisal

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Abstract

Purpose

Polycystic ovary syndrome (PCOS) is the most common endocrine-reproductive disease linked not just to infertility but also to serious comorbidities. There is a reported association between low vitamin D levels and multiple health conditions including PCOS. This narrative review aims to analyze the role of vitamin D in PCOS development, use of the vitamin D in the treatment of PCOS, and the molecular basis of these observations.

Methods

A Medline and PubMed research was performed, during the years 1990–2023, using a combination of keywords on such topic. According to the author's evaluation and target, papers were identified and included for a narrative review.

Results

There are associations between lower levels of vitamin D and PCOS, as well as with insulin resistance, metabolic syndrome, hyperandrogenemia, metabolic and endocrine disorders as well as the onset of oxidative stress and pro-inflammatory milieu, in PCOS women.

Conclusion

Vitamin D has a role in pathologic changes linked to PCOS. Molecular and clinical investigations which give new information about the role of vitamin D in the development of PCOS and related endocrine and metabolic disturbance are further needed.

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Data availability

It is not feasible for a review, as all the data belong to papers already published and included in the review.

References

  1. Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M, Nikfar S, Tsatsakis A, Abdollahi M (2022) Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing. Int J Mol Sci 23:583. https://doi.org/10.3390/ijms23020583

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Polycystic Ovary Syndrome. Accessed on 20. Mart 2023. https://www.womenshealth.gov/a-z-topics/polycystic-ovary-syndrome

  3. Patel S (2018) Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol 182:27–36. https://doi.org/10.1016/j.jsbmb.2018.04.008

    Article  CAS  PubMed  Google Scholar 

  4. Azziz R (2018) Polycystic ovary syndrome. Obstet Gynecol 132:321–336. https://doi.org/10.1097/AOG.0000000000002698

    Article  PubMed  Google Scholar 

  5. Patten RK, McIlvenna LC, Moreno-Asso A, Hiam D, Stepto NK, Rosenbaum S, Parker AG (2023) Efficacy of high-intensity interval training for improving mental health and health-related quality of life in women with polycystic ovary syndrome. Sci Rep 1:3025. https://doi.org/10.1038/s41598-023-29503-1

    Article  CAS  ADS  Google Scholar 

  6. Bednarska S, Siejka A (2017) The pathogenesis and treatment of polycystic ovary syndrome: What’s new? Adv Clin Exp Med 26:359–367. https://doi.org/10.17219/acem/59380

    Article  PubMed  Google Scholar 

  7. Peng G, Yan Z, Liu Y, Li J, Ma J, Tong N, Wang Y (2023) The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis. Reprod Biol Endocrinol 21:24. https://doi.org/10.1186/s12958-023-01075-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Michael W, Couture AD, Swedlund M, Hampton A, Eglash A, Schrager S (2022) An evidence-based review of vitamin d for common and high-mortality conditions. J Am Board Fam Med 35:1217–1229. https://doi.org/10.3122/jabfm.2022.220115R1

    Article  PubMed  Google Scholar 

  9. Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB (2022) The health effects of vitamin D supplementation: evidence from human studies. Nat Rev Endocrinol 18:96–110. https://doi.org/10.1038/s41574-021-00593-z

    Article  CAS  PubMed  Google Scholar 

  10. Franasiak JM, Lara EE, Pellicer A (2017) Vitamin D in human reproduction. Curr Opin Obstet Gynecol 29:189–194. https://doi.org/10.1097/GCO.0000000000000375

    Article  PubMed  Google Scholar 

  11. Grundmann M, von Versen-Höynck F (2011) Vitamin D - roles in women’s reproductive health? Reprod Biol Endocrinol 9:146. https://doi.org/10.1186/1477-7827-9-146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Fichera M, Török P, Tesarik J, Della Corte L, Rizzo G, Garzon S, Carlea A, Di Angelo Antonio S, Zito G, Panella MM (2020) Vitamin D, reproductive disorders and assisted reproduction: evidences and perspectives. Int J Food Sci Nutr 71: 276–285: https://doi.org/10.1080/09637486.2019.1661978.

  13. Malm G, Lindh CH, Hansson SR, Källén K, Malm J, Rylander L (2023) Maternal serum vitamin D level in early pregnancy and risk for preeclampsia: A case-control study in Southern Sweden. PLoS ONE 18:e0281234. https://doi.org/10.1371/journal.pone.0281234

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Hasan HA, Barber TM, Cheaib S, Coussa A (2023) Preconception vitamin d level and in vitro fertilization: pregnancy outcome. Endocr Pract 12: S1530–891X(23)00016–2. https://doi.org/10.1016/j.eprac.2023.01.005.

  15. Bindayel IA (2021) Low vitamin D level in saudi women with polycystic ovary syndrome. Front Nutr 8:611351. https://doi.org/10.3389/fnut.2021.611351

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ozyurt R, Karakus C (2022) Follicular fluid 25-hydroxyvitamin D levels determine fertility outcome in patients with polycystic ovary syndrome. Taiwan J Obstet Gynecol 61: 620–625: https://doi.org/10.1016/j.tjog.2022.03.041.

  17. Dokuzeylül Güngör N, Güngör K, Celik N, Önal M, Madenli AA (2023) Impact of body mass index and vitamin D on serum AMH levels and antral follicle count in PCOS. Eur Rev Med Pharmacol Sci 27:179–187. https://doi.org/10.26355/eurrev_202301_30870

    Article  PubMed  Google Scholar 

  18. Gokosmanoglu F, Onmez A, Ergenç H (2020) The relationship between Vitamin D deficiency and polycystic ovary syndrome. Afr Health Sci 20:1880–1886. https://doi.org/10.4314/ahs.v20i4.45

    Article  PubMed  PubMed Central  Google Scholar 

  19. Dawood AS, Elgergawy A, Elhalwagy A (2018) Circulating levels of vitamin d3 and leptin in lean infertile women with polycystic ovary syndrome. J Hum Reprod Sci 11:343–347. https://doi.org/10.4103/jhrs.JHRS_40_18

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Simpson S, Seifer DB, Shabanova V, Lynn AY, Howe C, Rowe E, Caprio S, Vash-Margita A (2020) The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. Reprod Biol Endocrinol 18:118. https://doi.org/10.1186/s12958-020-00676-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Bostanci EI, Ozler S, Yilmaz NK, Yesilyurt H (2018) Serum 25-hydroxy vitamin d levels in turkish adolescent girls with polycystic ovary syndrome and the correlation with clinical/biochemical parameters. J Pediatr Adolesc Gynecol 31:270–273. https://doi.org/10.1016/j.jpag.2017.07.008

    Article  PubMed  Google Scholar 

  22. Arslan E, Gorkem U, Togrul C (2019) Is there a relationship between vitamin d deficiency status and PCOS in infertile women? GeburtshilfeFrauenheilkd 79:723–730. https://doi.org/10.1055/a-0871-6831

    Article  CAS  Google Scholar 

  23. Nandi ER, Fatima P, Deeba F, Ara R, Dey S, Islam F (2023) Association between serum vitamin d and metabolic syndrome in women with polycystic ovary syndrome. Mymensingh Med J 32:125–134

    CAS  PubMed  Google Scholar 

  24. Krul-Poel YHM, Koenders PP, Steegers-Theunissen RP, Ten Boekel, E, Wee, MMT, Louwers, Y, Lips, P, Laven, JSE, Simsek, S (2018) Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): a cross-sectional study. PLoS ONE 13: e0204748: https://doi.org/10.1371/journal.pone.020474

  25. Wang L, Lv S, Li F, Yu X, Bai E, Yang X (2020) Vitamin D deficiency is associated with metabolic risk factors in women with polycystic ovary syndrome: a cross-sectional study in Shaanxi China. Front Endocrinol (Lausanne) 11:171. https://doi.org/10.3389/fendo.2020.00171

    Article  PubMed  Google Scholar 

  26. He C, Lin Z, Robb SW, Ezeamama AE (2015) Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients 7:4555–4577. https://doi.org/10.3390/nu7064555

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Łagowska K, Bajerska J, Jamka M (2018) The role of vitamin D Oral supplementation in insulin resistance in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutrients 10:1637. https://doi.org/10.3390/nu10111637

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Fang F, Ni K, Cai Y, Shang J, Zhang X, Xiong C (2017) Effect of vitamin D supplementation on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Clin Pract 26:53–60. https://doi.org/10.1016/j.ctcp.2016.11.008

    Article  PubMed  Google Scholar 

  29. Azadi-Yazdi M, Nadjarzadeh A, Khosravi-Boroujeni H, Salehi-Abargouei A (2017) The effect of vitamin d supplementation on the androgenic profile in patients with polycystic ovary syndrome: a systematic review and meta-analysis of clinical trials. Horm Metab Res 49:174–179. https://doi.org/10.1055/s-0043-103573

    Article  CAS  PubMed  Google Scholar 

  30. Jia XZ, Wang YM, Zhang N, Guo LN, Zhen XL, Li H et al (2015) Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: a meta-analysis. J Obstet Gynaecol Res 41:1791–1802. https://doi.org/10.1111/jog.12793

    Article  CAS  PubMed  Google Scholar 

  31. Pergialiotis V, Karampetsou N, Panagopoulos P, Trakakis E, Papantoniou N (2017) The effect of Vitamin D supplementation on hormonal and glycaemic profile of patients with PCOS: a meta-analysis of randomised trials. Int J Clin Pract. https://doi.org/10.1111/ijcp.12957

    Article  PubMed  Google Scholar 

  32. Santos BR, Lecke SB, Spritzer PM (2018) Apa-I polymorphism in VDR gene is related to metabolic syndrome in polycystic ovary syndrome: a cross-sectional study. Reprod Biol Endocrinol 16:38. https://doi.org/10.1186/s12958-018-0355-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Xavier LB, Gontijo NA, Rodrigues KF, Cândido AL, Dos Reis FM, de Sousa MCR, Silveira JN, Oliveira Silva IF, Ferreira, CN, Gomes, KB (2019) Polymorphisms in vitamin D receptor gene, but not vitamin D levels, are associated with polycystic ovary syndrome in Brazilian women. Gynecol Endocrinol 35:146–149: https://doi.org/10.1080/09513590.2018.1512966.

  34. Shahmoradi A, Aghaei A, Ghaderi K, Jafar Rezaei M, Azarnezhad A (2022) A meta-analysis of the association of ApaI, BsmI, FokI, and TaqI polymorphisms in the vitamin D receptor gene with the risk of polycystic ovary syndrome in the Eastern Mediterranean Regional Office population. Int J Reprod Biomed 20: 433–446: https://doi.org/10.18502/ijrm.v20i6.11439.

  35. Shi XY, Huang AP, Xie DW, Yu XL (2019) Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis. BMC Med Genet 20:32. https://doi.org/10.1186/s12881-019-0763-5

    Article  PubMed  PubMed Central  Google Scholar 

  36. Liang F, Ren N, Zhang H, Zhang J, Wu Q, Song R, Shi Z, Zhang Z, Wang K (2019) A meta-analysis of the relationship between vitamin D receptor gene ApaI polymorphisms and polycystic ovary syndrome. Adv Clin Exp Med 28:255–262. https://doi.org/10.17219/acem/85882

    Article  PubMed  Google Scholar 

  37. Niu YM, Wang YD, Jiang GB, Bai G, Chai HB, Li XF, Hu YY, Shen M (2019) Association Between Vitamin D Receptor Gene Polymorphisms and Polycystic Ovary Syndrome Risk: A Meta-Analysis. Front Physiol 9: 1902: doi: https://doi.org/10.3389/fphys.2018.01902.

  38. Várbíró S, Takács I, Tűű L, Nas K, Sziva RE, Hetthéssy JR et al (2022) Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome-A Review. Nutrients 14:1649. https://doi.org/10.3390/nu14081649

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN et al (2019) Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility. J Clin Endocrinol Metab 104:369–378. https://doi.org/10.1210/jc.2018-00750

    Article  PubMed  Google Scholar 

  40. Dastorani M, Aghadavod E, Mirhosseini N, Foroozanfard F, Zadeh Modarres S, Amiri Siavashani M, Asemi Z (2018) The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization. Reprod Biol Endocrinol 16:94. https://doi.org/10.1186/s12958-018-0413-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Maktabi M, Chamani M, Asemi Z (2017) The Effects of Vitamin D Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. HormMetab Res 49:493–498. https://doi.org/10.1055/s-0043-107242

    Article  CAS  Google Scholar 

  42. Javed Z, Papageorgiou M, Deshmukh H, Kilpatrick ES, Mann V, Corless L, Abouda G, Rigby AS, Atkin SL, Sathyapalan T (2019) A Randomized, Controlled Trial of Vitamin D Supplementation on Cardiovascular Risk Factors, Hormones, and Liver Markers in Women with Polycystic Ovary Syndrome. Nutrients 11:188. https://doi.org/10.3390/nu11010188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Trummer C, Schwetz V, Kollmann M, Wölfler M, Münzker J, Pieber TR, Pilz S, Heijboer AC, Obermayer-Pietsch B, Lerchbaum E (2019) Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial. Eur J Nutr 58:2019–2028. https://doi.org/10.1007/s00394-018-1760-8

    Article  CAS  PubMed  Google Scholar 

  44. Figurová J, Dravecká I, Petríková J, Javorský M, Lazúrová I (2017) The effect of alfacalcidiol and metformin on metabolic disturbances in women with polycystic ovary syndrome. Horm Mol Biol Clin Investig 29:85–91. https://doi.org/10.1515/hmbci-2016-0039

    Article  CAS  PubMed  Google Scholar 

  45. Razavi M, Jamilian M, Karamali M, Bahmani F, Aghadavod E, Asemi Z (2016) The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Horm Metab Res 48:446–451. https://doi.org/10.1055/s-0042-104060

    Article  CAS  PubMed  Google Scholar 

  46. Miao CY, Fang XJ, Chen Y, Zhang Q (2020) Effect of vitamin D supplementation on polycystic ovary syndrome: A meta-analysis. Exp Ther Med 19:2641–2649. https://doi.org/10.3892/etm.2020.8525

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Wang Q, Sun Y, Xu Q, Liu W, Wang P, Yao J et al (2022) Higher dietary inflammation potential and certain dietary patterns are associated with polycystic ovary syndrome risk in China: A case-control study. Nutr Res 100:1–18. https://doi.org/10.1016/j.nutres.2021.12.006

    Article  CAS  PubMed  Google Scholar 

  48. Shang Y, Zhou H, Hu M, Feng H (2020) Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome. J Clin Endocrinol Metab 105: dgaa425. doi: https://doi.org/10.1210/clinem/dgaa425.

  49. Norman AW, Okamura WH, Bishop JE, Henry HL (2002) Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol 197:1–13. https://doi.org/10.1016/s0303-7207(02)00273-3

    Article  CAS  PubMed  Google Scholar 

  50. Maestro B, Dávila N, Carranza MC (2003) Calle C (2003) Identification of a Vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 84:223–230. https://doi.org/10.1016/s0960-0760(03)00032-3

    Article  CAS  PubMed  Google Scholar 

  51. Maestro B, Molero S, Bajo S, Dávila N, Calle C (2002) Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3). Cell Biochem Funct 20:227–232. https://doi.org/10.1002/cbf.951

    Article  CAS  PubMed  Google Scholar 

  52. Contreras-Bolívar V, García-Fontana B, García-Fontana C, Muñoz-Torres M (2021) Mechanisms involved in the relationship between vitamin d and insulin resistance: impact on clinical practice. Nutrients 13:3491. https://doi.org/10.3390/nu13103491

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Milner RD, Hales CN (1967) The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia 3:47–49. https://doi.org/10.1007/BF01269910

    Article  CAS  PubMed  Google Scholar 

  54. Leung PS (2016) The potential protective action of vitamin d in hepatic insulin resistance and pancreatic islet dysfunction in type 2 diabetes mellitus. Nutrients 8:147. https://doi.org/10.3390/nu8030147

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Kjalarsdottir L, Tersey SA, Vishwanath M, Chuang JC, Posner BA, Mirmira RG, Repa JJ (2019) 1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor. J Steroid Biochem Mol Biol 185:17–26. https://doi.org/10.1016/j.jsbmb.2018.07.004

    Article  CAS  PubMed  Google Scholar 

  56. Wimalawansa SJ (2019) Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation, and aging. Biology (Basel) 8:30. https://doi.org/10.3390/biology8020030

    Article  CAS  PubMed  Google Scholar 

  57. Morgante G, Darino I, Spanò A, Luisi S, Luddi A, Piomboni P, Governini L, De Leo V (2022) PCOS physiopathology and vitamin D deficiency: biological insights and perspectives for treatment. J Clin Med 11:4509. https://doi.org/10.3390/jcm11154509

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Wei ZL, Yoshihara E, He N, Hah N, Fan W, Pinto AFM, Huddy, et al (2018) Vitamin D switches BAF complexes to protect β cells. Cell. https://doi.org/10.1016/j.cell.201

    Article  PubMed  PubMed Central  Google Scholar 

  59. Diamanti-Kandarakis E, Katsikis I, Piperi C, Kandaraki E, Piouka A, Papavassiliou AG, Panidis D (2008) Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf) 69:634–641. https://doi.org/10.1111/j.1365-2265.2008.03247.x

    Article  CAS  PubMed  Google Scholar 

  60. Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z (2017) Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. J Assist Reprod Genet 34:1507–1513. https://doi.org/10.1007/s10815-017-1011-6

    Article  PubMed  PubMed Central  Google Scholar 

  61. Merhi Z, Buyuk E, Cipolla MJ (2018) Advanced glycation end products alter steroidogenic gene expression by granulosa cells: an effect partially reversible by vitamin D. Mol Hum Reprod 24:318–326. https://doi.org/10.1093/molehr/gay014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Bianchi L, Gagliardi A, Landi C, Focarelli R, De Leo V, Luddi A, Bini L, Piomboni P (2016) Protein pathways working in human follicular fluid: the future for tailored IVF? Expert Rev Mol Med 18:e9. https://doi.org/10.1017/erm.2016.4

    Article  CAS  PubMed  Google Scholar 

  63. Irani M, Merhi Z (2014) Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 102:460–468. https://doi.org/10.1016/j.fertnstert.2014.04.046

    Article  CAS  PubMed  Google Scholar 

  64. Masjedi F, Keshtgar S, Zal F, Talaei-Khozani T, Sameti S, Fallahi S, Kazeroni M (2020) Effects of vitamin D on steroidogenesis, reactive oxygen species production, and enzymatic antioxidant defense in human granulosa cells of normal and polycystic ovaries. J Steroid Biochem Mol Biol 197:105521. https://doi.org/10.1016/j.jsbmb.2019.105521

    Article  CAS  PubMed  Google Scholar 

  65. Usluogullari B, Duvan C, Usluogullari C (2015) Use of aromatase inhibitors in practice of gynecology. J Ovarian Res 8:4. https://doi.org/10.1186/s13048-015-0131-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Echchgadda I, Song CS, Roy AK, Chatterjee B (2004) Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Mol Pharmacol 65:720–729. https://doi.org/10.1124/mol.65.3.720

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11000, Belgrade, Serbia

    Radmila Sparic

  2. Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia

    Radmila Sparic

  3. Clinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11000, Belgrade, Serbia

    Mladen Andjic

  4. Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Strada Prov. le Lecce-Monteroni, 73100, Lecce, Italy

    Daniele Vergara

  5. Department of Gynecology and Obstetrics, Pia Fondazione “Card. G. Panico”, Tricase, Lecce, Italy

    Andrea Morciano

  6. Department of Medical and Surgical Sciences and Translational Medicine, Translational Medicine and Oncology, Rome, Italy

    Ottavia D’Oria

  7. Department of Gynecological, Obstetrical and Urological Sciences, Sapienza University, Rome, Italy

    Ottavia D’Oria

  8. MOMO Ferti LIFE IVF Center, Bisceglie, Italy

    Giorgio Maria Baldini

  9. Department of Biomedical Sciences and Human Oncology, University of Bari, 70121, Bari, Italy

    Antonio Malvasi

  10. Department of Obstetrics and Gynecology and CERICSAL, (CEntro di RIcerca Clinico SALentino), Veris delli Ponti Hospital, Via Giuseppina delli Ponti, 73020, Scorrano, Lecce, Italy

    Andrea Tinelli

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RS: conceptualization, writing—original draft preparation, manuscript supervision, data collection. MA: manuscript review and editing, methodology, data analysis, supervision. DV: data analysis, methodology, writing—original draft preparation. AM: data analysis, methodology, writing—original draft preparation. OD: formal analysis, data curation. GMB: formal analysis, data curation. AM: formal analysis, data curation. AT: conceptualization, manuscript review and editing, manuscript supervision, data collection.

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Sparic, R., Andjic, M., Vergara, D. et al. PCOS and vitamin D: a clinical appraisal. Arch Gynecol Obstet 309, 907–915 (2024). https://doi.org/10.1007/s00404-023-07227-x

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