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The number of prior pregnancy losses does not impact euploidy rates in young patients with idiopathic recurrent pregnancy loss

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Our study aimed to determine the possible factors that might impact the probability of obtaining a euploid blastocyst following intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A) procedures in idiopathic recurrent pregnancy loss (RPL) patients.

Methods

This single-center retrospective cohort analysis included 180 oocyte retrieval cycles of 166 women under 35 years old and those diagnosed with idiopathic RPL according to American Society of Reproductive Medicine (ASRM) guidelines. Trophectoderm biopsy and next-generation sequencing (NGS) were the techniques used. Patients were stratified by the number of previous losses (Group A: 2, Group B: 3, and Group C: > 3).

Results

Baseline and embryological characteristics showed no statistically significant differences. The euploidy rate per analyzed blastocyst was comparable within the groups (63.3%, 58.2%, and 58.5%; p = 0.477). Logistic regression analyses confirmed that only the trophectoderm scores of A and B increased the probability of obtaining a euploid embryo [OR: 1.82, 95% CI (1.120–2.956), p: 0.016].

Conclusion

It is concluded that there was no correlation between the number of previous losses and the chance of finding at least one euploid embryo in ICSI cycles of women younger than 35 years.

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Data availability

https://doi.org/10.6084/m9.figshare.22121888.

Abbreviations

AH:

Assisted hatching

Array-CGH:

Array-based comparative genomic hybridization

ASRM:

American Society of Reproductive Medicine

BMI:

Body mass index

E2 :

Estradiol

GLMM:

Generalized linear mixed model

hCG:

Human chorionic gonadotropin

ICSI:

Intracytoplasmic sperm injection

ICM:

Inner cell mass

NGS:

Next-generation sequencing

P4 :

Progesterone

PGT-A:

Preimplantation genetic testing for aneuploidy

POCs:

Products of conception

RPL:

Recurrent pregnancy loss

SART-CORS:

Society for assisted reproductive technology clinical outcomes reporting system

SNP:

Single nucleotide polymorphism

TV-USG:

Transvaginal ultrasound

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Infertility Department, Bahceci Fulya IVF Center, Teşvikiye Mahallesi, Hakki Yeten Caddesi, Terrace Plaza, M3/11, Şişli, 34394, Istanbul, Turkey

    Niyazi Emre Turgut, Fazilet Kubra Boynukalin, Meral Gultomruk, Remzi Abali & Mustafa Bahceci

  2. Faculty of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey

    Niyazi Emre Turgut

  3. Department of Obstetrics and Gynecology, Uskudar University, Istanbul, Turkey

    Fazilet Kubra Boynukalin

  4. Faculty of Arts and Sciences, Department of Basic Sciences, Cyprus International, Kyrenia, Cyprus

    Zalihe Yarkiner

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  1. Niyazi Emre Turgut
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  3. Meral Gultomruk
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  4. Zalihe Yarkiner
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Contributions

TNE: protocol development, data analysis, manuscript writing. BFK: protocol development, manuscript writing. GM: data collection, data analysis. YZ: data analysis. AR: data collection. BM: manuscript editing. All the authors read and approved the final manuscript.

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Correspondence to Niyazi Emre Turgut.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethics approval

This study was approved by the Institutional Review Board on 24 January 2019 with a reference number of 48.

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Turgut, N.E., Boynukalin, F.K., Gultomruk, M. et al. The number of prior pregnancy losses does not impact euploidy rates in young patients with idiopathic recurrent pregnancy loss. Arch Gynecol Obstet 308, 1567–1575 (2023). https://doi.org/10.1007/s00404-023-07155-w

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