Abstract
Introduction
There is no clear correlation between abnormal umbilical cord blood gas studies (UCGS) and adverse neonatal outcome in low-risk deliveries. We investigated the need for its routine use in low-risk deliveries.
Methods
We retrospectively compared maternal, neonatal, and obstetrical characteristics among low-risk deliveries (2014–2022) between “normal” and “abnormal” pH groups: A:normal pH ≥ 7.15; abnormal pH < 7.15; B: normal pH ≥ 7.15 and base excess (BE) > − 12 mmol/L; abnormal pH < 7.15 and BE ≤ We retrospectively compared 12 mmol/L; C: normal pH ≥ 7.1; abnormal pH < 7.1; D: normal pH > 7.1 and BE > − 12 mmol/L; abnormal pH < 7.1 and BE ≤ − 12 mmol/L.
Results
Of 14,338 deliveries, the rates of UCGS were: A—0.3% (n = 43); B—0.07% (n = 10); C—0.11% (n = 17); D—0.03% (n = 4).
The primary outcome, composite adverse neonatal outcome (CANO) occurred in 178 neonates with normal UCGS (1.2%) and in only one case with UCGS (2.6%). The sensitivity and specificity of UCGS as a predictor of CANO were high (99.7–99.9%) and low (0.56–0.59%), respectively.
Conclusion
UCGS were an uncommon finding in low-risk deliveries and its association with CANO was not clinically relevant. Consequently, its routine use should be considered.
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References
Ahlberg M, Elvander C, Johansson S, Cnattingius S, Stephansson O (2017) A policy of routine umbilical cord blood gas analysis decreased missing samples from high-risk births. Acta Paediatr 106:43–48
Al Wattar BH, Honess E, Bunnewell S, Welton NJ, Quenby S, Khan KS, Zamora J, Thangaratinam S (2021) Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes: a systematic review and network meta-analysis. CMAJ 193:E468-e477
Armstrong L, Stenson BJ (2007) Use of umbilical cord blood gas analysis in the assessment of the newborn. Arch Dis Child Fetal Neonatal Ed 92:F430-434
Fahey J, King TL (2005) Intrauterine asphyxia: clinical implications for providers of intrapartum care. J Midwifery Womens Health 50:498–506
Ferreira CS, Melo Â, Fachada AH, Solheiro H, Nogueira Martins N (2018) Umbilical cord blood gas analysis, obstetric performance and perinatal outcome. Rev Bras Ginecol Obstet 40:740–748
Goldaber KG, Gilstrap LC 3rd, Leveno KJ, Dax JS, McIntire DD (1991) Pathologic fetal acidemia. Obstet Gynecol 78:1103–1107
Gonen N, Gluck O, Zussman NM, Bar J, Kovo M, Weiner E (2019) The role of umbilical cord gas studies in the prediction of adverse neonatal outcomes in scheduled nonlaboring term singleton cesarean deliveries. Am J Obstet Gynecol MFM 1:119–127
Goodwin TM, Belai I, Hernandez P, Durand M, Paul RH (1992) Asphyxial complications in the term newborn with severe umbilical acidemia. Am J Obstet Gynecol 167:1506–1512
Herrera CA, Silver RM (2016) Perinatal asphyxia from the obstetric standpoint: diagnosis and interventions. Clin Perinatol 43:423–438
Johnson GJ, Salmanian B, Denning SG, Belfort MA, Sundgren NC, Clark SL (2021) Relationship Between Umbilical Cord Gas Values and Neonatal Outcomes: Implications for Electronic Fetal Heart Rate Monitoring. Obstet Gynecol 138:366–373
Kaasen A, Aanstad KJ, Pay ASD, Økland I, Blix E (2019) National survey of routines for intrapartum fetal monitoring in Norway. Acta Obstet Gynecol Scand 98:390–395
Kelly R, Ramaiah SM, Sheridan H, Cruickshank H, Rudnicka M, Kissack C, Becher JC, Stenson BJ (2018) Dose-dependent relationship between acidosis at birth and likelihood of death or cerebral palsy. Arch Dis Child Fetal Neonatal Ed 103:F567-f572
Khoury AD, Moretti ML, Barton JR, Shaver DC, Sibai BM (1991) Fetal blood sampling in patients undergoing elective cesarean section: a correlation with cord blood gas values obtained at delivery. Am J Obstet Gynecol 165:1026–1029
Leybovitz-Haleluya N, Wainstock T, Pariente G, Sheiner E (2021) Non-reassuring fetal heart rate patterns: Is it a risk factor for long- term pediatric cardiovascular diseases of the offspring? Early Hum Dev 155:105330
Low JA, Lindsay BG, Derrick EJ (1997) Threshold of metabolic acidosis associated with newborn complications. Am J Obstet Gynecol 177:1391–1394
Malin GL, Morris RK, Khan KS (2010) Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. BMJ 340:c1471
Martis R, Emilia O, Nurdiati DS, Brown J (2017) Intermittent auscultation (IA) of fetal heart rate in labour for fetal well-being. Cochrane Database Syst Rev 2:Cd008680
National Collaborating Centre for Ws, Children's H (2014) National Institute for Health and Care Excellence: Clinical Guidelines. Intrapartum Care: Care of Healthy Women and Their Babies During Childbirth. National Institute for Health and Care Excellence (UK) Copyright © 2014 National Collaborating Centre for Women's and Children's Health, London
Sabol BA, Caughey AB (2016) Acidemia in neonates with a 5-minute Apgar score of 7 or greater—what are the outcomes? Am J Obstet Gynecol 215:486.e481-486
Thoresen M (2015) Who should we cool after perinatal asphyxia? Semin Fetal Neonatal Med 20:66–71
Thorp JA, Dildy GA, Yeomans ER, Meyer BA, Parisi VM (1996) Umbilical cord blood gas analysis at delivery. Am J Obstet Gynecol 175:517–522
Vanspranghels R, Houfflin-Debarge V, Deken V, Rakza T, Maboudou P, Storme L, Ghesquiere L, Garabedian C (2020) Umbilical cord arterial and venous gases, ionogram, and glucose level for predicting neonatal morbidity at term. Eur J Obstet Gynecol Reprod Biol 252:181–186
Victory R, Penava D, Da Silva O, Natale R, Richardson B (2004) Umbilical cord pH and base excess values in relation to adverse outcome events for infants delivering at term. Am J Obstet Gynecol 191:2021–2028
White CR, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE (2010) Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit. Aust N Z J Obstet Gynaecol 50:318–328
Wiklund I, Ahlberg M, Dahlström A, Weichselbraun M, Sjörs G (2014) Routine testing of umbilical cord blood after normal delivery should be discontinued. Sex Reprod Healthc 5:165–166
Xodo S, Xodo L, Berghella V (2018) Delayed cord clamping and cord gas analysis at birth. Acta Obstet Gynecol Scand 97:7–12
Yeh P, Emary K, Impey L (2012) The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51,519 consecutive validated samples. BJOG 119:824–831
Zaigham M, Källén K, Olofsson P (2019) Gestational age-related reference values for Apgar score and umbilical cord arterial and venous pH in preterm and term newborns. Acta Obstet Gynecol Scand 98:1618–1623
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EB: project development, data collection and management, data analysis, manuscript writing and editing. NG: project development, data collection and management, data analysis, manuscript writing and editing. IC: project development, data collection and management, data analysis, manuscript writing and editing. AS: project development. DJ: data collection. GB: project development. OG: data analysis. Eran Weiner: project development, data collection and management, data analysis, manuscript writing and editing.
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Gonen, N., Cohen, I., Gluck, O. et al. Umbilical cord blood gases sampling in low-risk vaginal deliveries as a predictor of adverse neonatal outcome. Arch Gynecol Obstet 309, 523–531 (2024). https://doi.org/10.1007/s00404-023-06965-2
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DOI: https://doi.org/10.1007/s00404-023-06965-2