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Effect of bacterial vaginosis on preterm birth: a meta-analysis

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Bacterial vaginosis is a common genital tract disorder. It can lead to preterm birth, but its contribution is equivocal. Bacterial vaginosis is curable and, if diagnosed and appropriately treated, may reduce preterm births. The study desired to confirm the association between bacterial vaginosis and preterm birth.

Methods

It was a meta-analysis. We included articles published from 2008 to 2022. The authors included studies that measured the association between bacterial vaginosis and preterm birth by relative risk/risk ratio (RR) or odds ratio (OR). We excluded studies with qualitative data. The study utilized five search engines, PubMed, Scopus, Google Scholar, Cochrane, and LILAC. We used the statistical package for social sciences (SPSS) to draw forest and funnel plots separately for RR and OR.

Results

After an extensive search, the study included 20 articles yielding 26 relevant results with a total of 290,397 observations. This meta-analysis proves that bacterial vaginosis is undoubtedly associated with preterm birth. The overall relative risk of preterm delivery is about two-fold as overall OR1.79 (95% Confidence Interval 1.32–2.43). The overall RR of preterm birth is 1.44 (95% Confidence Interval 1.19–1.73).

Conclusion

Our study shows a significant association between bacterial vaginosis and preterm birth. The study concludes that investigation for bacterial vaginosis and management should be a part of the routine examination of a pregnant woman. The health system must initiate this strategy soon to reduce the prevalence of preterm births and consequent neonatal mortality.

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Acknowledgements

We are thankful to Dr. Jayashree Gothankar, Professor and Head, Dr. Varsha Vaidya Professor, Dr. Prasad Pore, Professor, and Dr. Rupeshkumar Deshmukh, Statistician Department of Community Medicine, Bharati Vidyapeeth Deemed University Medical College.

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TM initiated the study, searched references, wrote the manuscript. PPD conceptualized the study, finalized the manuscript. SRK assisted reference search and manuscript writing. All authors have approved final manuscript.

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Correspondence to Prakash Prabhakarrao Doke.

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After obtaining the Institutional Ethics Committee’s (DCGI Regd. No. ECR/518/Inst/MH/2014/RR-17) permission, the study was conducted.

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Mohanty, T., Doke, P.P. & Khuroo, S.R. Effect of bacterial vaginosis on preterm birth: a meta-analysis. Arch Gynecol Obstet 308, 1247–1255 (2023). https://doi.org/10.1007/s00404-022-06817-5

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