Abstract
Purpose
Pruritus during pregnancy is associated with adverse maternal, pregnancy, and neonatal outcomes. We opted to assess the association between term pruritus and long-term neuropsychiatric hospitalizations of the offspring.
Methods
In a population-based retrospective cohort study, the incidence of long-term neuropsychiatric hospitalizations was compared between offspring born to women with or without pruritus at term. Neuropsychiatric morbidity was assessed up to the age of 18 years according to ICD-9 codes associated with hospitalization of the offspring. A Kaplan–Meier survival curve was used to compare cumulative neuropsychiatric hospitalizations incidence and Cox proportional hazards models were used to control for confounders. The study included 226,918 deliveries of which 600 (0.26%) were in women with term pruritus.
Results
Offspring born to women with pruritus exhibited a higher rate of long-term neuropsychiatric hospitalizations, specifically due to developmental and neurodegenerative disorders. Kaplan–Meier survival curve demonstrated a significantly higher cumulative incidence of long-term neuropsychiatric hospitalizations in offspring of women with pruritus. Using several Cox proportional hazards models, being born to a woman with pruritus was independently associated with an increased risk of long-term neuropsychiatric hospitalizations.
Conclusions
Maternal term pruritus was found to be independently associated with long-term neuropsychiatric hospitalizations of the offspring.
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Conceptualization, ES and GP; methodology, ES; software, ES; validation, ES; formal analysis, ES; investigation, OL and GP; resources, GP; data curation, ES; writing—original draft preparation, OL; writing—review and editing, OL, GP, ES, and DK; visualization, OL; supervision, GP and ES; project administration, GP All authors have read and agreed to the published version of the manuscript.
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The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of Soroka University Medical Center (SUMC) (protocol code SOR-19-0357, date of approval 10 October 2019).
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Levanony, O., Sheiner, E., Kluwgant, D. et al. Maternal term pruritus and long-term neuropsychiatric hospitalizations of the offspring. Arch Gynecol Obstet 308, 857–862 (2023). https://doi.org/10.1007/s00404-022-06742-7
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DOI: https://doi.org/10.1007/s00404-022-06742-7