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Prevalence and genotype distribution of human papillomavirus infection among female outpatients in Northeast China: a population-based survey of 110,927 women

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Abstract

Purpose

Human papillomavirus (HPV) infection, especially high-risk HPV, is a major etiological factor for cervical cancer. This study aimed to investigate the distribution of human papillomavirus infection among female outpatients in Northeast China.

Methods

A total of 110,927 women aged between 18 and 80 years from Shengjing Hospital of China Medical University, tested with the HPV Geno-Array Test Kit (HybriBio), were enrolled in this study.

Results

The overall prevalence of HPV infection in the study population was 16.95% (18,802/110,927). A total of 21 HPV genotypes were identified and the six most prevalent ones were HPV16 (5.78%), HPV58 (2.62%), HPV52 (1.91%), HPV33 (1.55%), HPV53 (1.45%), and HPV18 (1.16%). The prevalence of single HPV was 83.58% (15,714/18802) and that of multiple HPV was 16.42% (3088/18802). HPV16, HPV58, and HPV52 were the most common types of HR-HPV infections, while CP8304, HPV11, and HPV6 were the most common types of LR-HPV infections. Among the multiple infection groups, HPV16 was the most common type of co-infection. Furthermore, the prevalence of HPV infections varied among different age groups. Age-specific prevalence of HPV exhibited two peaks in the youngest age group and in the group aged 50–60 years.

Conclusion

HPV16, 58, 52, 33, 53, and 18 were the most common types in the general female population. The prevalence of HPV infection varied among different age groups. This study provides guidance for future HPV-based cervical cancer screening tests and prophylactic HPV vaccinations in China.

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Acknowledgements

The authors thank everyone who helped in this study.

Funding

This work was supported by the Free Researcher Project of Shengjing Hospital (grant #201302).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

    Huijie Zhang & Shulan Zhang

Authors
  1. Huijie Zhang
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  2. Shulan Zhang
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Contributions

SZ: Project development, Data Collection. HZ: Data collection, Manuscript writing.

Corresponding author

Correspondence to Shulan Zhang.

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The authors have no conflicts of interest.

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Ethical approval was obtained for all studies included in this analysis.

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Zhang, H., Zhang, S. Prevalence and genotype distribution of human papillomavirus infection among female outpatients in Northeast China: a population-based survey of 110,927 women. Arch Gynecol Obstet 308, 35–41 (2023). https://doi.org/10.1007/s00404-022-06653-7

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