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Maternal condyloma acuminata infection in pregnancy and offspring long-term respiratory and infectious outcome

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Maternal condyloma acuminata infection may be vertically transmitted to the offspring during pregnancy and childbirth. Our study aimed to investigate the possible impact of maternal condyloma acuminata infection in pregnancy on offspring respiratory and infectious morbidity.

Methods

A population‐based cohort analysis including all singleton deliveries occurring between 1991 and 2014 at a tertiary medical center. Long-term infectious and respiratory morbidities were compared between children with and without exposure to maternal condyloma infection during pregnancy. A Kaplan–Meier survival curve was used to compare cumulative hospitalization rate and a Cox regression analyses to control for confounders.

Results

No significant differences were found in total respiratory and infectious related hospitalizations between the study groups. The survival curves demonstrated no difference in the cumulative incidence between the two groups in both respiratory hospitalizations (log-rank, p = 0.18) and infectious hospitalizations (log-rank, p = 0.95). Cox multivariable analyses demonstrated that exposure to maternal condyloma infection during pregnancy is not a risk factor for neither infectious (aHR 0.91, [CI] 0.49–1.69) nor respiratory (aHR 0.37, [CI] 0.09–1.51) morbidity during childhood and adolescence.

Conclusion

Exposure to maternal condyloma infection during pregnancy does not appear to be an independent risk factor for later respiratory or infectious morbidity throughout childhood and adolescence.

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Acknowledgements

This study was conducted as part of the requirements for an MD degree from the Goldman Medical School at the Faculty of Health Sciences, Ben-Gurion University of the Negev. Ofir Sahar wrote the first draft of the manuscript. No honorarium, grant, or other form of payment was given to anyone to produce the manuscript.

Funding

This study was not funded.

Author information

Authors and Affiliations

  1. Faculty of Health Sciences, Joyce and Irving Goldman Medical School, Ben Gurion University of the Negev, 151 Izak Rager Ave, 84101, Beer-Sheva, Israel

    Ofir Sahar

  2. Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Gil Gutvirtz & Eyal Sheiner

  3. Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Tamar Wainstock

Authors
  1. Ofir Sahar
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  2. Gil Gutvirtz
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  4. Eyal Sheiner
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Contributions

OS: Writing original draft, visualization. GG: Conceptualization, writing review and editing, supervision. TW: Formal analysis, conceptualization, development or design of methodology, validation, writing review and editing; ES: Conceptualization, writing review and editing, supervision.

Corresponding author

Correspondence to Ofir Sahar.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Sahar, O., Gutvirtz, G., Wainstock, T. et al. Maternal condyloma acuminata infection in pregnancy and offspring long-term respiratory and infectious outcome. Arch Gynecol Obstet 307, 1423–1429 (2023). https://doi.org/10.1007/s00404-022-06631-z

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  • DOI: https://doi.org/10.1007/s00404-022-06631-z

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