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Impact of inflammatory factors, hemoglobin A1c, and platelet parameters in gestational diabetes mellitus

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to evaluate the relationship among inflammatory cytokines including hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6), glycated hemoglobin A1c (HbA1c), and platelet distribution width (PDW) in women with gestational diabetes mellitus (GDM).

Methods

Data on 191 pregnant women (96 women with GDM; 95 healthy controls) were extracted from routine prenatal examination records in Nanjing, China. Fasting concentrations of hs-CRP, IL-6, HbA1c, blood cell indices, and glucose at 24–28th gestational weeks were determined.

Results

The levels of hs-CRP, IL-6, FPG, PG1h, PG2h, HbA1c, RBC, and PDW significantly were increased (P < 0.05) in GDM group. hs-CRP had a positive correlation with HbA1c and PLT (P < 0.05). The odds ratios of HbA1c and PDW were 7.817 (95% CI 1.921–31.816, P = 0.004) and 1.523 (95% CI 1.158–2.002, P = 0.003), respectively. Furthermore, AUC of the combined diagnosis of GDM including HbA1c, FPG, and PDW reached 0.754, with specificity of 80.0% and sensitivity of 60.4%.

Conclusion

Our findings support that elevated levels of hs-CRP, IL-6, HbA1c, and PDW at 24–28th gestational weeks even within the conventional normal range, may be implicated in the pathogenesis of GDM and their evaluation should be part of prenatal care routine.

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Availability of data and materials

All relevant data are within the manuscript.

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Acknowledgements

We thank Shu-Qin Shen for her coordination and contribution to the laboratory.

Funding

The study was supported by National Natural Science Foundation of China (No. 81870546), Nanjing Medical Science and Technique Development Foundation (No. YKK17177), and Science and Technology Development Foundation Item of Nanjing Medical University (NMUB2020124).

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Author notes

  1. Lan-Lan Xiang and Chen Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical Laboratory, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, 21000, Jiangsu Province, China

    Lan-Lan Xiang, Chen Chen, Yi-Tian Zhu, Ya-Jun Chen & Yu Zeng

  2. School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 21000, Jiangsu Province, China

    Qian-Yi Wang

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  1. Lan-Lan Xiang
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Contributions

LX and CC performed experiments, analyzed the data, and interpreted the results of experiments. QW and YZ prepared the figures and participated in the discussion. YC participated in the discussion and provided funding to reagents. YZ wrote the manuscript, provided funding to reagents, and approved the final version of the manuscript.

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Correspondence to Yu Zeng.

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Xiang, LL., Chen, C., Wang, QY. et al. Impact of inflammatory factors, hemoglobin A1c, and platelet parameters in gestational diabetes mellitus. Arch Gynecol Obstet 307, 439–446 (2023). https://doi.org/10.1007/s00404-022-06528-x

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