Abstract
Aims
Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes.
Methods
Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia—HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6–5.9 mg/dL) groups. Poisson regression models (prevalence ratio—PR; 95% confidence interval—95% CI), multinomial logistic regression (odds ratio—OR; 95% CI), and Pearson's correlation (correlation coefficient—r) were applied by taking into consideration p < 0.05 as significance level.
Results
The total sample comprised 267 pregnant women with PE. HU was observed in 25.8% of patients; it was associated with black pregnant women (p = 0.014) and with primiparity (p = 0.007). Uric acid levels were higher in early PE cases than in late PE cases (p = 0.013); however, there was no significant difference between mild and severe PE cases (p = 0.121). Uric acid recorded a positive correlation to urea (p < 0.001), creatinine (p = 0.002), glutamic-oxaloacetic transaminase (p < 0.001), glutamic-pyruvic transaminase (p = 0.005), ferritin (p = 0.002) and globulin (p = 0.002); as well as negative correlation to platelets (p = 0.035), lactic dehydrogenase (p = 0.039) and albumin (p > 0.001). HU was a factor associated with cesarean delivery (p = 0.030), prematurity (p = 0.001), low birth weight (p < 0.001) and small for gestational age (p = 0.020).
Conclusion
High serum uric acid levels were associated with early-onset PE. Maternal features were correlated to biochemical parameters linked to PE severity and to adverse perinatal outcomes.
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Acknowledgements
The authors gratefully acknowledge financial support from the National Council for Scientific and Technological Development—CNPq and the Alagoas State Research Support Foundation—FAPEAL (PPSUS/CNPq/SESAU-AL/FAPEAL process 60030 000818/ 2016).
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Research financed by the Research Program for the Brazilian Unified Health System—PPSUS.
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ELSSM: Conception of the study, data analysis and the writing of the article; JVFS: Conception and design of the study, and data Collection; CSM: Conception and design of the study, and critical review; ACMO: Conception and design of the study, data analysis, and critical review.
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de Mendonça, E.L.S.S., da Silva, J.V.F., Mello, C.S. et al. Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes. Arch Gynecol Obstet 305, 1453–1463 (2022). https://doi.org/10.1007/s00404-021-06313-2
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DOI: https://doi.org/10.1007/s00404-021-06313-2