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Juvenile granulosa cell tumor in pregnancy: case series and literature review

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Pregnancy complicated with juvenile granulosa cell tumor (JGCT) is very rare; thus, the experience on clinical diagnosis and management is limited.

Cases

Two patients presented with abdominal pain, two were incidentally discovered, one by ultrasonography, and one during a caesarian section. One case received an emergency caesarian section because of tumor rupture at 38th week’s gestation, the rest were treated at full term and no abnormalities were detected in the newborns. Three cases received further staging surgery, two of which received postoperative adjuvant chemotherapy. No patient had recurrent disease after a follow-up period spanning from 13 to 57 months.

Conclusion

In the absence of emergency, surgery can be delayed without affecting the fetus. More research is needed to determine the value of chemotherapy in FIGO stage I patients.

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Availability of data and materials

All data generated or analyzed during this study are included in this published article.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Elijah Ndhlovu, Jun Dai, Xiyuan Dong & Biao Chen

  2. Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Hui Deng

  3. Department of Pathology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China

    Lili Liu

Authors
  1. Elijah Ndhlovu
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  2. Hui Deng
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  3. Jun Dai
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  4. Xiyuan Dong
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  5. Lili Liu
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  6. Biao Chen
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Contributions

E Ndhlovu: study design, data collection, data analysis, manuscript writing. B Chen: study design, data collection, data analysis, manuscript revision. J Dai: data collection, data analysis, manuscript checking. XY Dong: data collection, data analysis, manuscript checking. H Deng: data collection, data analysis, manuscript revision. L Liu: study design, data collection, data analysis, manuscript revision.

Corresponding authors

Correspondence to Lili Liu or Biao Chen.

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The authors declare that they have no competing interests.

Ethical approval

This study was approved by the Tongji Hospital Medical Ethics Committee (approval number: 20200317).

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Informed consent to participate has been obtained from all the patients.

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Written patient consent for publication from all the patients has been obtained.

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Ndhlovu, E., Deng, H., Dai, J. et al. Juvenile granulosa cell tumor in pregnancy: case series and literature review. Arch Gynecol Obstet 305, 1299–1310 (2022). https://doi.org/10.1007/s00404-021-06283-5

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  • DOI: https://doi.org/10.1007/s00404-021-06283-5

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