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Association of nausea and vomiting of pregnancy with infant growth in the first 24 months of life

  • General Gynecology
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Abstract

Purpose

We aimed to investigate the association of maternal nausea and vomiting during pregnancy (NVP) with infant growth in the first 24 months of life and compare the effect of fetal gender.

Methods

This prospective cohort study was conducted in Zhoushan Maternal and Child Health Hospital, Zhejiang, from 2011 to 2018. 1942 pairs of singleton newborns and their mothers were selected as participants. Main outcomes were gestational weight gain (GWG), birth outcomes (birthweight and gestational age) and infant growth [weight, height, weight/height-for-age Z score (WAZ/HAZ), the weight gain during childhood]. The associations of NVP with birth outcomes and infant growth at children’s age of 1, 3, 6, 12, 18, and 24 months were analyzed by multivariable regression models.

Results

Of the 1942 women, 1395 had NVP at first trimester (T1) and among them, 210 still experienced NVP at second trimester (T2). Compared with women without NVP, women experienced severe NVP at T1 were related with lower total GWG. Mild and moderate NVP at T1 were negatively associated with lower birthweight among women with male infants. Female infants exposed to maternal NVP at T1, especially for severe degree, were showed greater weight, WAZ, height, HAZ, and weight gain after 1 year old (at age of 12, 18, 24 months). No association between maternal NVP and infant growth was observed among male infants.

Conclusion

Exposure to NVP at T1 was, respectively, associated with lower GWG. Favorable influence of NVP at T1 on infant growth was observed among female offspring.

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Acknowledgements

We thank for the support from faculties and staffs in Zhoushan Maternal and Child Care Hospital and all participants in this study.

Funding

This work was funded by Chinese National Natural Science Foundation (81973055), the National Key Research and Development Program of China (2016YFC1305301), Key Research and Development Projects of Zhejiang Science and Technology Department (2018C03010), Project of Science and Technology of Zhejiang Medical and Health (2013KYB273 and 2015RCA230), and Project of Science and Technology of Zhoushan (2015C31038), and Project of Science and Technology of Zhoushan Medical and Health (2015A02).

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Author notes

  1. Leijun Gu and Minjia Mo equally contributed to the manuscript.

Authors and Affiliations

  1. Zhoushan Maternal and Child Care Hospital, Zhoushan, China

    Leijun Gu & Wen Jiang

  2. Department of Public Health, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

    Minjia Mo, Shuting Si, Wenliang Luo, Bule Shao, Xing Xin & Yunxian Yu

  3. Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

    Yunxian Yu

  4. Department of Obstetrics and Gynaecology, Woman’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Danqing Chen

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  1. Leijun Gu
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Contributions

LJG: participants enrollment, MJM: data acquisition, analysis and interpretation, STS: data management, XX: data collection, WLL: data analysis, BLS: data acquisition, DQC, YXY: manuscript editing and WJ: Project development.

Corresponding author

Correspondence to Yunxian Yu.

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We declare that we have no conflict of interest.

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Protocol of this study was approved by the institutional review board of School of Medicine, Zhejiang University.

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Each participant provided the informed consent form before investigation.

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Gu, L., Mo, M., Si, S. et al. Association of nausea and vomiting of pregnancy with infant growth in the first 24 months of life. Arch Gynecol Obstet 304, 429–438 (2021). https://doi.org/10.1007/s00404-021-06046-2

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