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Histopathological correlation of cervical biopsy and tissue after excision in patients with precancerous lesions of the cervix

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Cervical intraepithelial neoplasia (CIN) are precancerous lesion of cervix, with incidence of 1.6 per 1000 for CIN 1 lesion and 1.2 per 1000 for CIN 3 lesion in USA. According to IARC incidence is higher in less developed and developing countries. Taking into account the fact that the sensitivity, specificity and accuracy of Papanicolaou swab and colposcopy vary, the final diagnosis is made by colposcopically guided biopsy and by excisions of the cervix.

Aim of the study

Comparing the histopathological findings of cervical biopsy and definitive histopathological findings after cervical excision in precancerous lesions of the cervix in relation to the degree of lesion, age and institution, where the biopsy was performed.

Materials and methods

The study was retrospective and was conducted on a group of patients who underwent some excision techniques on the cervix after obtaining a histological finding of the cervical biopsy.

Results

In a total sample of 168 patients, a correlation of histopathological analysis of biopsy material and excision techniques was observed in 62.5% (105/168). This correlation was statistically significant (χ2 = 5.333, df 1; p = 0.0209). The greater correlation of histopathological material of biopsies and final histopathological material after excisions were obtained in Oncology Institute of Vojvodina (OIV) without statistical significance.

Conclusion

A statistically significant accuracy of biopsy was noted in examined group of patients.

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Funding

This study was not funded by any company.

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Authors and Affiliations

  1. Oncology Institute of Vojvodina Sremska Kamenica, Sremska Kamenica, Serbia

    Aljoša Mandić, Nemanja Stevanović, Bojana Gutic, Slobodan Maričić, Zoran Nikin & Nenad Šolajić

  2. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

    Aljoša Mandić, Bojana Gutic, Slobodan Maričić, Zoran Nikin & Nenad Šolajić

Authors
  1. Aljoša Mandić
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  2. Nemanja Stevanović
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  3. Bojana Gutic
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  4. Slobodan Maričić
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  5. Zoran Nikin
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  6. Nenad Šolajić
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Contributions

AM—project development, data collection, manuscript writing, management, data analysis. NS—data collection, data analysis, manuscript writing. BG—data collection, data analysis, Management. SM—data collection, data analysis. ZN—data collection, data analysis. NŠ—data collection, data analysis.

Corresponding author

Correspondence to Aljoša Mandić.

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Mandić, A., Stevanović, N., Gutic, B. et al. Histopathological correlation of cervical biopsy and tissue after excision in patients with precancerous lesions of the cervix. Arch Gynecol Obstet 304, 223–230 (2021). https://doi.org/10.1007/s00404-020-05911-w

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  • DOI: https://doi.org/10.1007/s00404-020-05911-w

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