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Comparison of metabolic and obesity biomarkers between adolescent and adult women with polycystic ovary syndrome

  • General Gynecology
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Abstract

Purpose

Knowledge of adolescent and adult phenotypes of women with polycystic ovary syndrome (PCOS) might drive opportune management. The aim of this study was to compare metabolic and obesity biomarkers between adolescent and adult women with PCOS.

Methods

This observational study compared biomarkers of obesity and metabolism derangements between adolescent (n = 62) and adult (n = 248) women with PCOS. Predictors of metabolic syndrome (MS) were investigated using univariate and multivariate binary logistic regression analysis.

Results

The postmenarcheal age of adolescents was 4.9 ± 0.03 years. Systolic blood pressure was lower in adolescents than in adults (112.3 mmHg vs 117.0 mmHg, p = 0.001) Diastolic blood pressure was also lower in adolescents (70.7 mmHg vs 75.8 mmHg, p < 0.001). Glucose intolerance (12.0% vs 19.3%) and insulin resistance (18.2% vs 17.7%) were similar in both groups (p > 0.05, for comparisons). Impaired fasting glucose was lower in adolescents (1.8% vs 11.6%, p = 0.015). Total cholesterol and low-density lipoprotein cholesterol were lower in adolescents (p < 0.001). MS in adolescents and adults were found in 10.3% and 27.8%, respectively (p = 0.005). Visceral adiposity index (VAI) was a good predictor of MS in both adolescents (OR = 12.2), and adults (OR = 9.7).

Conclusions

Most biomarkers of glucose metabolism abnormalities were similar in adolescents and adults with PCOS. The prevalence of MS was lower in adolescents. VAI was a strong predictor of metabolic syndrome, both in adolescent and adult women with PCOS.

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The authors are grateful to Liberty Medical Communications, LLC, for English proofreading.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, MT, 78 043 306, Brazil

    Sebastião Freitas de Medeiros

  2. Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil

    Sebastião Freitas de Medeiros, Matheus Antônio Souto de Medeiros, Bruna Barcelo Barbosa & Márcia Marly Winck Yamamoto

  3. Disciplina de Ginecologia, Departamento de Obstetrícia E Ginecologia, Faculdade de Medicina de São Paulo, Hospital das Clínicas, São Paulo, Brazil

    Gustavo Arantes Rosa Maciel

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SFdM: design, data description, statistical analysis, and writing the manuscript. MASdM: data search, revision of the manuscript. BBB: data search, data analysis, revision of the manuscript. MMWY: data search, revision of the manuscript. GARM: data search, revision of the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Sebastião Freitas de Medeiros.

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de Medeiros, S.F., de Medeiros, M.A.S., Barbosa, B.B. et al. Comparison of metabolic and obesity biomarkers between adolescent and adult women with polycystic ovary syndrome. Arch Gynecol Obstet 303, 739–749 (2021). https://doi.org/10.1007/s00404-020-05867-x

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