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Relationship between contraceptive methods and human papillomavirus positivity

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Understanding the effect of contraceptive use on high-risk human papillomavirus (HPV) positivity may provide information that is valuable to women in contraceptive decision-making. This study includes women aged 30–65 years who admitted to Family Planing outpatient clinic and have hrHPVDNA positivity.

Methods

We included a total of 801 women. All participants underwent national cervical cancer screening using HPV screening test conducted by the Cancer Control Department of the Ministry of Health. They completed a questionnaire on demographic information and potential risk factors.

Results

The HPV DNA positivity rate among all participants was 8.4%. The two most common HPV genotypes were HPV16 and HPV51. Meanwhile, hrHPV infection was associated with age, marital status, smoking status, and contraceptive method.

Conclusion

HPV is the most common cause of sexually transmitted diseases. Understanding about the reproductive and demographic characteristics affecting HPV persistence is crucial. The effect of contraceptive methods on HPV positivity is important information that is necessary to be relayed to women by healthcare professionals.

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References

  1. Burd EM, Dean CL (2016) Human papillomavirus. Microbiol Spec 4:177–195

    Google Scholar 

  2. Dunne EF, Park IU (2013) HPV and HPV-associated diseases. Infect Dis Clin North Am 27(765–78):765–778

    Article  Google Scholar 

  3. Rodríguez AC, Schiffman M, Herrero R, Wacholder S, Hildesheim A, Castle PE et al (2008) Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections. J Natl Cancer Inst 100:513–517

    Article  Google Scholar 

  4. Roura E, Castellsagué X, Pawlita M, Travier N, Waterboer T, Margall N et al (2014) Smoking as a major risk factor for cervical cancer and pre-cancer: results from the EPIC cohort. Int J Cancer 135:453–466

    Article  CAS  Google Scholar 

  5. Xu H, Egger S, Velentzis LS, O’Connell DL, Banks E, Darlington-Brown J et al (2018) Hormonal contraceptive use and smoking as risk factors for high-grade cervical intraepithelial neoplasia in unvaccinated women aged 30–44 years: a case-control study in New South Wales. Australia Cancer Epidemiol 55:162–169

    Article  Google Scholar 

  6. Gultekin M, Zayifoglu Karaca M, Kucukyildiz I, Dundar S, Boztas G, Semra Turan H et al (2018) Initial results of population based cervical cancer screening program using HPV testing in one million Turkish women. Int J Cancer 142:1952–1958

    Article  CAS  Google Scholar 

  7. Averbach S, Silverberg MJ, Leyden W, Smith-McCune K, Raine-Bennett T, Sawaya GF (2018) Recent intrauterine device use and the risk of precancerous cervical lesions and cervical cancer. Contraception 98:130–134

    Article  Google Scholar 

  8. Castellsagué X, Díaz M, Vaccarella S, de Sanjosé S, Muñoz N, Herrero R et al (2011) Intrauterine device use, cervical infection with human papillomavirus, and risk of cervical cancer: a pooled analysis of 26 epidemiological studies. Lancet Oncol 12:1023–1031

    Article  Google Scholar 

  9. Cortessis VK, Barrett M, Brown Wade N, Enebish T, Perrigo JL, Tobin J et al (2017) Intrauterine device use and cervical cancer risk: a systematic review and meta-analysis. Obstet Gynecol 130:1226–1236

    Article  Google Scholar 

  10. Sandmire HF, Austin SD, Bechtel RC (1976) Carcinoma of the cervix in oral contraceptive steroid and IUD users and nonusers. Am J Obstet Gynecol 125:339–345

    Article  CAS  Google Scholar 

  11. Lassise DL, Savitz DA, Hamman RF, Barón AE, Brinton LA, Levines RS (1991) Invasive cervical cancer and intrauterine device use. Int J Epidemiol 20:865–870

    Article  CAS  Google Scholar 

  12. Li HQ, Thomas DB, Jin SK, Wu F (2000) Tubal sterilization and use of an IUD and risk of cervical cancer. J Womens Health Gend Based Med 9:303–310

    Article  CAS  Google Scholar 

  13. Roura E, Travier N, Waterboer T, de Sanjosé S, Bosch FX, Pawlita M et al (2016) The influence of hormonal factors on the risk of developing cervical cancer and pre-cancer: results from the EPIC Cohort. PLoS ONE 11:e0147029

    Article  Google Scholar 

  14. Curtis KM, Marchbanks PA, Peterson HB (2007) Neoplasia with the user of intrauterine devices. Contraception 75:S60–S69

    Article  Google Scholar 

  15. Epstein RJ (2003) Hormonal contraception and cervical cancer. Lancet 361:1915

    Article  Google Scholar 

  16. Ylitalo N, Sørensen P, Josefsson A, Frisch M, Sparén P, Pontén J et al (1999) Smoking and oral contraceptives as risk factors for cervical carcinoma in situ. Int J Cancer 81:357–365

    Article  CAS  Google Scholar 

  17. Gadducci A, Barsotti C, Cosio S, Domenici L, Genazzani R (2011) Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature. Gynecol Endocrinol 27(8):597–604

    Article  Google Scholar 

  18. Alam S, Conway MJ, Chen HS, Meyers C (2008) The cigarette smoke carcinogen benzo[a]pyrene enhances human papillomavirus synthesis. J Virol 82:1053–1058

    Article  CAS  Google Scholar 

  19. Su B, Qin W, Xue F, Wei X, Guan Q, Jiang W et al (2018) The relation of passive smoking with cervical cancer: a systematic review and meta-analysis. Medicine 97:e13061

    Article  Google Scholar 

  20. Shi N, Lu Q, Zhang J, Li L, Zhang J, Zhang F et al (2017) Analysis of risk factors for persistent infection of asymptomatic women with high-risk human papilloma virus. Hum Vaccin Immunother 13:1–7

    Article  Google Scholar 

  21. Liang Y, Chen M, Qin L, Wan B, Wang H (2019) A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia. Infect Agents Cancer 14:29

    Article  CAS  Google Scholar 

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Funding

This study was not supported by any funding.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Medical Sciences, Etlik Zubeyde Hanım Training and Research Hospital, Ankara, Turkey

    Fulya Kayikcioglu, Müzeyyen Gunes, Runa Özelci, Berna Dilbaz & Serdar Dilbaz

  2. Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, İmaret/Sivas, Merkez/Sivas, 58140, Sivas, Turkey

    Irem Alyazici Kucukyildiz

Authors
  1. Fulya Kayikcioglu
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  2. Irem Alyazici Kucukyildiz
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  3. Müzeyyen Gunes
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  4. Runa Özelci
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  5. Berna Dilbaz
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  6. Serdar Dilbaz
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Contributions

Data curation: İAK, FK, RO, MG; Formal analysis: İAK, FK; Investigation: İAK, RO; Methodology: FK, MG, RO; Project administration: İAK, FK; Resources: İAK, MG; Software: İAK, RO; Supervision: FK, SD, BD; Writing—original draft: İAK, FK, RO; Writing—review and editing: İAK, FK, RO, MG, SD, BD.

Corresponding author

Correspondence to Irem Alyazici Kucukyildiz.

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Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

All procedures performed in this study were in accordance with the institutional ethical standards and the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was not obtained from the participants included in this study because of the retrospective nature of the study.

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Kayikcioglu, F., Kucukyildiz, I.A., Gunes, M. et al. Relationship between contraceptive methods and human papillomavirus positivity. Arch Gynecol Obstet 302, 1407–1412 (2020). https://doi.org/10.1007/s00404-020-05754-5

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  • DOI: https://doi.org/10.1007/s00404-020-05754-5

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