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Are maternal metabolic syndrome and lipid profile associated with preterm delivery and preterm premature rupture of membranes?

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Aim

We aimed to evaluate the association of metabolic syndrome (MetS), its components and lipid profile in mid-pregnancy with preterm delivery and preterm premature rupture of membranes (PPROM).

Methods

This prospective cohort study was conducted on 203 pregnant women between 24 and 28 weeks of gestation, undergoing gestational diabetes screening test with 50 g glucose challenge test (GCT). Fasting serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels were measured during the week after GCT assessment. Information on the participants’ pre-pregnancy weight, demographic/reproductive characteristics, and height and blood pressure (BP) measurements were documented at baseline entry into the study. Metabolic syndrome was defined as the co-existence of 3 or more of the following criteria: Body mass index (BMI) before pregnancy ≥ 30 kg/m2, BP ≥ 130/85 mmHg, GCT ≥ 140 mg/dl, TG ≥ 150 mg/dl, and HDL-C ≤ 50 mg/dl. All participants were followed through routine prenatal care, up to delivery. Any deliveries or rupture of membranes of less than 37 weeks of pregnancy were considered preterm delivery and PPROM, respectively. Statistical analysis was performed by SPSS V.20, and p value of less than 0.05 was considered significant.

Findings

MetS was detected in 10 (4.9%) of participants. Logistic regression analysis showed HDL-C levels, and hypertension were associated with spontaneous preterm delivery [(OR 0.952, 95% CI 0.910–0.995), (OR 1.629, 95% CI 1.554–1.709) respectively], but no statistically significant results were found for PPROM.

Conclusions

Low HDL-C levels and hypertension in mid-pregnancy are associated with the occurrence of spontaneous preterm deliveries, indicating that MetS and its components should be monitored more closely in pregnancy.

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Funding

This study was performed as the thesis project for a M.Sc. degree in Midwifery in Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. No external funding sources were provided for this study.

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Authors and Affiliations

  1. Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, Al-e-Ahmad Highway, Tehran, Iran

    Shiva Niyaty, Lida Moghaddam-Banaem & Hadis Sourinejad

  2. Department of Medical Sciences, Qom Branch, Islamic Azad University, Qom, Iran

    Samira Mokhlesi

Authors
  1. Shiva Niyaty
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  2. Lida Moghaddam-Banaem
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  4. Samira Mokhlesi
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Correspondence to Lida Moghaddam-Banaem.

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This research was approved by the Ethical Committee of the Faculty of Medical Sciences in Tarbiat Modares University, Tehran, Iran.

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Informed written consent was obtained from all participants.

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Niyaty, S., Moghaddam-Banaem, L., Sourinejad, H. et al. Are maternal metabolic syndrome and lipid profile associated with preterm delivery and preterm premature rupture of membranes?. Arch Gynecol Obstet 303, 113–119 (2021). https://doi.org/10.1007/s00404-020-05738-5

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  • DOI: https://doi.org/10.1007/s00404-020-05738-5

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