Abstract
For clinical purposes, diagnostic added value of HE4 is important. Diagnostic knowledge is not provided by answering the question, “How accurate is this test?” (test accuracy research). Diagnostic knowledge is the information needed to answer the question, “What is the probability of the presence or absence of a specific disease given these test results?” (diagnostic accuracy research). Therefore, diagnostic added value of HE4 expression (differences of ROC curves for two diagnostic models with and without HE4) is important in clinical practice. Without assessing reliability, we cannot judge about diagnostic value. The diagnostic value is estimated by two parameters: reliability and accuracy.
This is a preview of subscription content, log in via an institution to check access.
References
Li W, Wang D (2020) The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125. Arch Gynecol Obstet 301(5):1219–1225. https://doi.org/10.1007/s00404-020-05527-0
Szklo M, Nieto FJ (2014) Epidemiology beyond the basics, 3rd edn. Jones and Bartlett Publisher, New York
Grobbee DE, Hoes AW (2015) Clinical epidemiology: principles, methods, and applications for clinical research, 2nd edn. Jones and Bartlett Publisher, Burlington
Sabour S (2017) A common mistake in assessing the diagnostic value of a test: failure to account for statistical and methodologic issues. J Nucl Med 58(7):1182–1183. https://doi.org/10.2967/jnumed.115.156745
Naderi M, Sabour S (2018) Reproducibility of diagnostic criteria associated with atypical breast cytology: a methodological issue. Cytopathology 29(4):396. https://doi.org/10.1111/cyt.12560
Pirouzpanah S, Taleban FA, Mehdipour P, Atri M, Hooshyareh-rad A, Sabour S (2014) The biomarker-based validity of a food frequency questionnaire to assess the intake status of folate, pyridoxine and cobalamin among Iranian primary breast cancer patients. Eur J Clin Nutr 68(3):316–323. https://doi.org/10.1038/ejcn.2013.209
Baharvand M, Manifar S, Akkafan R, Mortazavi H, Sabour S (2014) Serum levels of ferritin, copper, and zinc in patients with oral cancer. Biomed J 37(5):331–336. https://doi.org/10.4103/2319-4170.132888
Sabour S, Ghassemi F (2012) Accuracy, validity, and reliability of the infrared optical head tracker (IOHT). Investig Ophthalmol Vis Sci 53(8):4776. https://doi.org/10.1167/iovs.12-10324
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
S. Sabour declares that he has no conflict of interest.
Ethical approval
This article does not contain any studies with human participants performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sabour, S. The differential diagnostic value of serum HE4 in ovarian disease with elevated CA125; importance of diagnostic added value in clinical practice. Arch Gynecol Obstet 302, 1041–1042 (2020). https://doi.org/10.1007/s00404-020-05681-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-020-05681-5