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Prenatal exposure to isolated amniotic fluid disorders and the risk for long-term endocrine morbidity of the offspring

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Amniotic fluid abnormalities may be associated with adverse perinatal outcomes, some of which are endocrine related.

Objective

To evaluate whether in utero exposure to amniotic fluid abnormalities is associated with long-term endocrine morbidity in the offspring.

Study design

In this cohort study, the incidence of long-term endocrine disorders was compared between singletons exposed and non-exposed to oligohydramnios or polyhydramnios.

Results

During the study period, 195 943 newborns were included in the study, of them 2.0% (n = 4072) and 2.9% (n = 5684) were exposed to oligohydramnios and polyhydramnios, respectively. Long-term endocrine morbidity was higher among children exposed to isolated amniotic fluid disorders, as was also noted in the Kaplan–Meier survival curve (log-rank test p < 0.001). Abnormal amniotic fluid volume was found to be independently associated with long-term endocrine morbidity of the offspring according to a Cox regression model controlled for clinically related confounders.

Conclusion

In utero exposure to isolated amniotic fluid abnormalities is independently associated with long-term endocrine morbidity in the offspring.

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Funding

This study did not receive any funding.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 151, 84101, Beer-Sheva, Israel

    Gali Pariente, Asnat Walfisch & Eyal Sheiner

  2. Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Tamar Wainstock & Ruslan Sergienko

  3. Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Daniella Landau

Authors
  1. Gali Pariente
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  2. Asnat Walfisch
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  3. Tamar Wainstock
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  4. Daniella Landau
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  5. Ruslan Sergienko
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  6. Eyal Sheiner
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Contributions

PG: Study design, data interpretation. WA: Study design, data interpretation. WT: Data collection, data analysis, generation of figures. LD: Pediatric consultation. SR: Data collection, data analysis. SE: Study design, data interpretation. All authors were involved in writing the paper and had final approval of the submitted version.

Corresponding author

Correspondence to Eyal Sheiner.

Ethics declarations

Conflict of interest

Gali Pariente declares that she has no conflict of interests, Asnat Walfisch declares that she has no conflict of interests, Tamar Wainstock declares that she has no conflict of interests, Daniella Landau declares that she has no conflict of interests, Ruslan Sergienko declares that he has no conflict of interests, Eyal Sheiner declares that he has no conflict of interests.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was not needed to be obtained from individual participants included in the study as the individual identity was not known to the study researchers at any time.

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Pariente, G., Walfisch, A., Wainstock, T. et al. Prenatal exposure to isolated amniotic fluid disorders and the risk for long-term endocrine morbidity of the offspring. Arch Gynecol Obstet 302, 873–878 (2020). https://doi.org/10.1007/s00404-020-05674-4

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  • DOI: https://doi.org/10.1007/s00404-020-05674-4

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