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Clinical characteristics difference between early and late recurrence of ovarian endometriosis after laparoscopic cystectomy

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Ovarian endometriosis is the most frequent type of endometriosis. Despite the use of surgery and medication, many patients suffer from recurrence within near future. Currently, there are no effective clinical characteristics available to predict the time to recurrence in ovarian endometriosis patients.

Purpose

To identify the effective clinical indicators for early and late endometrioma recurrence, we compared the clinical characteristics of early and late recurrence after treatment.

Methods

We collected 358 patients with ovarian endometriosis who had a minimum of 5 years of postoperative follow-up after undergoing a laparoscopic excision of ovarian endometrioma performed at Peking Union Medical College Hospital from January 2009 to April 2013.

Results

A total of 358 patients were recruited in the validation set, with a median follow-up time of 83 months (60–120 months). Till the last follow-up, 68 patients exhibited recurrence. Three-year and 5-year recurrence rates were 9.2% and 15.4%, respectively. Univariate analysis in our study showed that patient with endometrioma surgery history had higher incidence of recurrence in 3 years after re-surgery (OR: 5.594, P = 0.029). Univariate and multivariate analyses using the logistic regression showed that the presence of tenesmus before surgery affected the incidence of early recurrence with a ratio of 57.9% (11/19) and 89.5% (17/19) in 3 years and 5 years after surgery, respectively.

Conclusions

Presence of tenesmus before surgery may be linked to the early recurrence of endometrioma.

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Availability of data and materials

The dataset supporting the conclusions of this article is included within the article and its additional files.

Abbreviations

ART:

Artificial reproduction technology

ASRM:

American Society for Reproductive Medicine

BMI:

Body mass index

CA-125:

Carbohydrate antigen 125

CI:

Confidence interval

DIE:

Deep invasive endometriosis

GnRHa:

Gonadotropin-releasing hormone agonist

OR:

Odds ratio

QoL:

Quality of life

TTR:

Time to recurrence

VAS:

Visual analog scale

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Acknowledgments

None.

Funding

Our work was supported by the National Key R&D Program of China (No. 2017YFC1001200), National Natural Science Foundation of China (No. 81501237), and 2016 PUMCH Science Fund for Junior Faculty (No. PUMCH-2016-2.2).

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Author notes

  1. Xiaoyan Li and Wen Zhang contribute equally to this article.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Shuaifuyuan No. 1, Dongcheng District, Beijing, 100730, China

    Xiaoyan Li, Xiaopei Chao, Yi Dai, Jinghua Shi, Shuangzheng Jia, Sikai Chen, Yushi Wu, Zhiyue Gu & Jinhua Leng

  2. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China

    Wen Zhang

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  1. Xiaoyan Li
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Contributions

JL: study conception and design. XL: manuscript writing. WZ: data analysis. XC, YD, JS: data collection. SJ, SC, YW: pathological investigation. The manuscript has been read and approved by all the authors. The requirements for authorship have been met. Each author believes that the manuscript represents honest work.

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Correspondence to Jinhua Leng.

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This study was approved by the Ethics Committee of Peking Union Medical College Hospital.

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Li, X., Zhang, W., Chao, X. et al. Clinical characteristics difference between early and late recurrence of ovarian endometriosis after laparoscopic cystectomy. Arch Gynecol Obstet 302, 905–913 (2020). https://doi.org/10.1007/s00404-020-05657-5

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