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An investigation of the time trends, risk factors, role of ultrasonic preoperative diagnosis of 79 ovarian pregnancy

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Ovarian pregnancy (OP) is a rare form of ectopic pregnancy and is still a medical challenge. Therefore, more studies about the time trends, risk factors and diagnostic measurements are needed for the efficient treatment of OP.

Methods

The datum of OP patients who were treated at the Second Hospital of Hebei Medical University from 2003 to 2018 was collected and a retrospective cohort study was preformed between OP and tubal pregnancy.

Results

79 of all 6943 ectopic pregnancy (1.14%) were OP. The prevalence of OP following assisted reproductive technology showed an increasing trend over time, from 8.33% to 15.22%. Previous abdominal surgery was one of the risk factors of OP (OR 0.41, 95% CI 0.18–0.95, p = 0.04). Merely 2 (2.53%) patients were sonographically diagnosed as OP accorded with their discharge diagnosis. However, 56 (80.0%) accumulation of blood in the pelvis formed echo free areas could be clearly found by ultrasonography. A significant difference was found in serum β-hCG level among OP patients and tubal pregnancy patients (2762.73 ± 1915.24 mmol/L vs 1034.20 ± 915.32 mmol/L, p < 0.001).

Conclusions

The prevalence of OP following assisted reproductive technology is on the rise. History of abdominal surgery may be a high risk factor for OP patients who have the tendency of high β-hCG levels. The ultrasonic preoperative diagnosis is conductive to the early diagnosis of OP though the diagnosis accuracy is low.

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Acknowledgements

The authors would like to thank Dr. Liu Bin for contributing to the draft manuscript.

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Author notes

  1. Jia-Hua Zheng and Meng-Di Liu contributed equally to this study and share first authorship.

Authors and Affiliations

  1. Department of Gynecology, Second Hospital of Hebei Medical University, No. 215, He Ping Road (West), Xin Hua District, Shijiazhuang, Hebei, China

    Jia-Hua Zheng, Ming-le Zhang & Xiang-Hua Huang

  2. Department of Reproduction, Second Hospital of Hebei Medical University, No. 215, He Ping Road (West), Xin Hua District, Shijiazhuang, Hebei, China

    Meng-Di Liu & Wei Wang

  3. Department of Obstetrics and Gynecology Ultrasound Diagnosis and Treatment, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

    Xiao-Jing Zhou

  4. Department of Pathology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

    Yu-Mei Ma

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Contributions

WW, XHH, JHZ and MDL had designed the research. JHZ and MDL drafted the manuscript. JHZ, MDL, XJZ, MLZ and YMM collected all the data, analyzed the data and made all the figures and tables in this manuscript. WW and XHH had guided the writing. All authors read and approved the final manuscript.

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Correspondence to Wei Wang or Xiang-Hua Huang.

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This respective study was approved by the Research and Ethical Committee of the Second Hospital of Hebei Medical University, China, basing on the 1964 Helsinki declaration and its later amendments.

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The submission of this manuscript has been approved by all authors.

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Zheng, JH., Liu, MD., Zhou, XJ. et al. An investigation of the time trends, risk factors, role of ultrasonic preoperative diagnosis of 79 ovarian pregnancy. Arch Gynecol Obstet 302, 899–904 (2020). https://doi.org/10.1007/s00404-020-05648-6

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  • DOI: https://doi.org/10.1007/s00404-020-05648-6

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