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A novel non-invasive molecular biomarker in ovarian endometriosis: estrogen-related receptor α

  • General Gynecology
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to explore whether estrogen-related receptors α (ERRα) can prognosticate the occurrence and development of ovarian endometriosis (EMs) as a non-invasive biomarker.

Methods

The ectopic and its’ correspond eutopic endometria from 47 patients with ovarian EMs and the control normal endometria from 32 cases were collected and detected the mRNA expression of ERRα by RT-qPCR. The serum protein of ERRα were tested by ELISA. The menstrual cycle, ovarian cyst sizes, relative clinical tumour markers, such as CA125, CA19-9 and HE-4, and other demographic data were also involved into analysis in these patients by SPSS 22.0 (IBM, Chicago, IL, USA).

Results

The ERRα mRNA expression in ectopic endometria were significantly lower than it in eutopic endometria (P < 0.05) and the normal endometria (P < 0.05). Similarly, the serum ERRα levels in patients with EMs were significantly lower than it in control group (P < 0.01). Moreover, the serum ERRα levels were decreasing with the increasing of the pathological stages and ovarian cyst sizes. While, the serum CA125, CA19-9, CA125/ERRα ratio and CA19-9/ERRα ratio in the study group were significantly higher than those in the control group (all P < 0.01).

Conclusion

The expression of ERRα is correlated with the development of ovarian EMs pathological stages and ovarian cyst sizes and can be used as a novel and non-invasive biomarker for evaluating the progression of ovarian EMs.

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References

  1. Giudice LC (2010) Clinical practice. Endometriosis. N Engl J Med 362:2389–2398

    Article  CAS  Google Scholar 

  2. Vercellini P, Vigano P, Somigliana E, Fedele L (2014) Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol 10:261–275

    Article  CAS  Google Scholar 

  3. Huhtinen K, Desai R, Stahle M et al (2012) Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels. J Clin Endocrinol Metab 97:4228–4235

    Article  CAS  Google Scholar 

  4. Ya G, Minghui S, Xueni Ma et al (2019) Seven hormonal biomarkers for diagnosing endometriosis: a meta-analysis and adjusted indirect comparison of diagnostic test accuracy. J Minim Invasive Gynecol 26(6):1026–1035

    Article  Google Scholar 

  5. Tanida T, Matsuda KI, Yamada S, Hashimoto T, Kawata M (2015) Estrogen-related receptor beta reduces the subnuclear mobility of estrogen receptor alpha and suppresses estrogen-dependent cellular function. J Biol Chem 290:12332–12345

    Article  CAS  Google Scholar 

  6. Yang Y, Yang W (2017) Epithelial-to-mesenchymal transition in the development of endometriosis. Oncotarget 8:41679–41689

    Article  Google Scholar 

  7. Wei W, Schwaid AG, Wang X et al (2016) Ligand activation of ERRalpha by cholesterol mediates statin and bisphosphonate effects. Cell Metab 23:479–491

    Article  CAS  Google Scholar 

  8. Thewes V, Simon R, Schroeter P et al (2015) Reprogramming of the ERRalpha and ERalpha target gene landscape triggers tamoxifen resistance in breast cancer. Cancer Res 75:720–731

    Article  CAS  Google Scholar 

  9. Matsushima H, Mori T, Ito F et al (2016) Anti-tumor effect of estrogen-related receptor alpha knockdown on uterine endometrial cancer. Oncotarget 7:34131–34148

    Article  Google Scholar 

  10. Wang C, Hsu W, Tai C (2017) Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor α in human ovarian carcinoma cells. Oncotarget 8:3049–3058

    Article  Google Scholar 

  11. Cavallini A, Resta L, Caringella AM, Dinaro E, Lippolis C, Loverro G (2011) Involvement of estrogen receptor-related receptors in human ovarian endometriosis. Fertil Steril 96:102–106

    Article  CAS  Google Scholar 

  12. Han JY, Lee EJ, Jee BC, Kim SH (2018) Menstrual characteristics in Korean women with endometriosis: a pilot study. Obstet Gynecol Sci 61:142–146

    Article  Google Scholar 

  13. Foster W (2016) Diagnosing endometriosis:CA125 rules in, but not out. BJOG 123:1769

    Article  CAS  Google Scholar 

  14. Bombail V, MacPherson S, Critchley HO, Saunders PT (2008) Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle. Hum Reprod 23:2782–2790

    Article  CAS  Google Scholar 

  15. Luo J, Sladek R, Carrier J, Bader J-A, Richard D, Giguère V (2003) Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α. Mol Cell Biol 23:7947–7956

    Article  CAS  Google Scholar 

  16. Cong J, Li P, Zheng L, Tan J (2016) Prevalence and risk factors of infertility at a rural site of Northern China. PLoS ONE 11:e0155563

    Article  Google Scholar 

  17. Acimovic M, Vidakovic S, Milic N et al (2016) Surviving and VEGF as novel biomarkers in diagnosis of endometriosis. J Med Biochem 35:63–68

    Article  CAS  Google Scholar 

  18. Mabrouk M, Elmakky A, Caramelli E et al (2012) Performance of peripheral (serum and molecular) blood markers for diagnosis of endometriosis. Arch Gynecol Obstet 285:1307–1312

    Article  CAS  Google Scholar 

  19. Kurdoglu Z, Gursoy R, Kurdoglu M, Erdem M, Erdem O, Erdem A (2009) Comparison of the clinical value of CA 19–9 versus CA 125 for the diagnosis of endometriosis. Fertil Steril 92:1761–1763

    Article  CAS  Google Scholar 

  20. Agic A, Djalali S, Wolfler MM, Halis G, Diedrich K, Hornung D (2008) Combination of CCR1 mRNA, MCP1, and CA125 measurements in peripheral blood as a diagnostic test for endometriosis. Reprod Sci 15:906–911

    Article  Google Scholar 

  21. Tuten A, Kucur M, Imamoglu M et al (2014) Copeptin is associated with the severity of endometriosis. Arch Gynecol Obstet 290:75–82

    Article  CAS  Google Scholar 

  22. Wei WD, Ruan F, Tu FX et al (2013) Expression of suppressor of cytokine signaling-3 and caspase-3 in endometriosis and their correlation. Zhonghua Bing LI Xue Za Zhi 42:515–518

    CAS  PubMed  Google Scholar 

  23. Giguere V (2008) Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev 29:677–696

    Article  CAS  Google Scholar 

  24. Yang C, Zhou DJ, Chen S (1998) Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor. Cancer Res 58:5695–5700

    CAS  PubMed  Google Scholar 

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Author notes

  1. Chen Liu and YaoJia Chen have contributed equally to this work.

Authors and Affiliations

  1. Department of Blood Transfusion, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, No. 18 Daoshan Road, Fuzhou, 350001, China

    Chen Liu

  2. Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, No. 18 Daoshan Road, Fuzhou, 350001, China

    YaoJia Chen, XiaoDan Mao, BinHua Dong & PengMing Sun

  3. Fujian Key Laboratory of Women and Children’s Critical Diseases Research, No. 18 Daoshan Road, Fuzhou, 350001, China

    YaoJia Chen, XiaoDan Mao, BinHua Dong & PengMing Sun

  4. Department of Medical Laboratory, Fujian Medical University, No. 88 Jiaotong Road, Fuzhou, 350004, China

    Min Chen

Authors
  1. Chen Liu
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  2. YaoJia Chen
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  3. Min Chen
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Contributions

CL: study designation and manuscript writing; YJC: manuscript writing and statistical analysis; MC: data interpretation; XDM: laboratory analysis; BHD: statistical analysis; PMS: critically revised the article and supervised the study.

Corresponding author

Correspondence to PengMing Sun.

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Conflict of interest

The authors have no conflict of interest to declare.

Ethical approval

The study was approved by our institutional review board (2016-038).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Liu, C., Chen, Y., Chen, M. et al. A novel non-invasive molecular biomarker in ovarian endometriosis: estrogen-related receptor α. Arch Gynecol Obstet 302, 405–414 (2020). https://doi.org/10.1007/s00404-020-05611-5

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  • DOI: https://doi.org/10.1007/s00404-020-05611-5

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