Abstract
Purpose
To explore whether the adverse pregnancy outcomes in first frozen embryo transfer (FET) cycles affect live birth and neonatal outcomes in the subsequent pregnancy?
Methods
This was a retrospective study. Women with a history of adverse pregnancy outcomes in first FET cycles started their subsequent embryo transfer cycles. The adverse pregnancy outcomes included biochemical pregnancy, ectopic pregnancy, and first-trimester pregnancy loss. The main outcomes of present study were live birth rate and neonatal outcomes.
Results
Results showed patients with first-trimester pregnancy loss in first FET cycles had a 95 percent greater chance of live birth in subsequent FET cycles (OR 1.95, 95% CI 1.33–2.88). However, the biochemical pregnancy/ectopic pregnancy in initial FET cycles did not affect the chance of live birth in second cycles (biochemical pregnancy: OR 1.21, 95% CI 0.82–1.77; ectopic pregnancy: OR 1.06, 95% CI 0.55–2.05). The neonatal outcomes of singletons were not affected by the number of embryo transfer cycles.
Conclusions
Patients with first-trimester pregnancy loss in first FET cycle had a greater chance of live birth in second FET cycles, but the biochemical pregnancy/ectopic pregnancy in first FET cycles did not significantly affect the live birth in second FET cycles. The three types of adverse pregnancy outcomes in first FET cycles did not affect neonatal outcomes in the second cycles.
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Acknowledgements
The authors wish to express their thanks to all clinicians and clinical embryologists in the Department of Assisted Reproduction.
Funding
This work was supported by National Natural Science Foundation of China (Grant Nos. 81903324, 81771533, 81571397 and 81701523).
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YPK and QQZ designed the study. QQZ and JHL drafted the manuscript. JYL and YMR conducted the data acquisition and statistical analysis. YPK revised the manuscript. All authors read and approved the final manuscript.
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Li, J., Lin, J., Yin, M. et al. The live birth and neonatal outcomes in the subsequent pregnancy among patients with adverse pregnancy outcomes in first frozen embryo transfer cycles. Arch Gynecol Obstet 302, 731–740 (2020). https://doi.org/10.1007/s00404-020-05608-0
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DOI: https://doi.org/10.1007/s00404-020-05608-0