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Influence of a mannose-binding lectin gene polymorphism and exposure to Chlamydia trachomatis on fallopian tube obstruction in Brazilian woman

  • General Gynecology
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Abstract

Purpose

Factors influencing fallopian tube occlusion in women with a lower genital tract infection remain incompletely elucidated. We evaluated whether a polymorphism in the mannose-binding lectin (MBL) gene at codon 54 influences the occurrence of fallopian tube blockage in relation to exposure to Chlamydia trachomatis.

Methods

In a case–control study at The Hospital das Clínicas, University of São Paulo, Brazil, 75 women with hysterosalpingography-documented tubal occlusion and 75 women with patent fallopian tubes were analyzed for detection of single-nucleotide polymorphism in codon 54 of the MBL gene and for IgG anti-C. trachomatis antibodies in their sera. Both groups were matched for age, race, and sexual variables.

Results

Prior exposure to C. trachomatis, as evidenced by the presence of IgG antibodies, was comparable in both groups. Detection of the polymorphic MBL allele was more prevalent in women with blocked tubes (p < 0.01), regardless of whether or not there was evidence of prior chlamydial exposure.

Conclusion

The level of MBL-related innate immunity influences the consequences of infection by C. trachomatis or other microbes.

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Authors and Affiliations

Authors

Contributions

JGV, SCR, IML: trial conception and design, wrote original draft. EIF, RR, JGV, CCO: patient recruitment, sample collection, initial data analysis. IML, SSW: final data analysis and interpretation, wrote final version of manuscript. IML, ECB: study supervision.

Corresponding author

Correspondence to Steven S. Witkin.

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None of the authors report any conflict of interest.

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Vinagre, J.G., Witkin, S.S., Ribeiro, S.C. et al. Influence of a mannose-binding lectin gene polymorphism and exposure to Chlamydia trachomatis on fallopian tube obstruction in Brazilian woman. Arch Gynecol Obstet 300, 641–645 (2019). https://doi.org/10.1007/s00404-019-05231-8

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  • DOI: https://doi.org/10.1007/s00404-019-05231-8

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