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Association of trimester-specific gestational weight gain with birth weight and fetal growth in a large community-based population

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Previous studies showed that the association of gestational weight gain (GWG) with fetal birthweight and offspring developmental growth was unclear. The aim of this study is to investigate the respective effect of 1 kg of GWG during three trimesters on birthweight and offspring growth from birth to 3 years of age.

Methods

We extracted the decoded information from the Maternal and Child Health Information Management System of Zhoushan Maternal and Child Health Hospital in Zhejiang, China from October 2001 to March 2015, and used multiple linear and logistic regression models.

Results

This study included 20,232 women with a full-term singleton birth and 15,557 newborns who took regular health check-ups. Compared to that in the 2nd and 3rd trimester, 1 kg GWG increasing in the 1st trimester had the strongest positive association with higher birthweight, body weight, and height from 1 to 36 months. Their associations with BMI after birth were similar among the three trimesters. In addition, some positive dose–response effects found between quartiles of GWG in the 1st trimester and offspring body weight, as well as BMI. The 1 kg GWG in 1st trimester played the strongest role in contributing to birth weight and benefiting to body growth among children aged up to 3 years.

Conclusion

The 1 kg GWG in 1st trimester contributed more to birth weight and body development from birth to 3 years compared to the 2nd and 3rd trimesters. The possible beneficial effects of GWG in the 1st trimester on birthweight and offspring development in under/normal weight mothers are found.

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Funding

This work was supported by the National Key Research and Development Programme of China (2016YFC1305301), Projects of Science and Technology Plan of Zhejiang Province (2014C33243), Medical Health Science and Technology Project of Zhejiang Province (2013KYB273), Science and Technology Project of Zhoushan (2013C31066), Medical Health Science and Technology Key Project of Zhoushan (2013G02), Medical Health Science and Technology Project of Zhejiang Province (2014KYA277), Medical Health Science and Technology Key Project of Zhoushan (2014A03), Science and Technology Project of Zhoushan (2015C31038).

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Author notes

  1. Yafei Mao and Shuojia Wang and equally contributed to this manuscript.

Authors and Affiliations

  1. Zhoushan Maternal and Child Care Hospital, Zhoushan, Zhejiang, China

    Yafei Mao, Leijun Gu, Hongyu Lian & Liuyan Pu

  2. Department of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

    Shuojia Wang, Minchao Li, Manxian Huang, Minjia Mo, Xiamusiye Muyiduli, Shuying Jiang, Zhaopin Wang, Bule Shao & Yunxian Yu

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  1. Yafei Mao
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Contributions

YM: Obtaining data and review. SW: Manuscript writing, data curation. ML: Data analysis. MH: Investigation. MM: Methodology. LG: Project administration, resources. XM: Validation and review. HL: Validation, visualization. SJ: Visualization, writing. ZW: Writing and review. BS: Review and editing. LP: Revise the paper. YY: Project development

Corresponding author

Correspondence to Yunxian Yu.

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The authors declare no conflict of interest.

Ethical approval

This study protocol was approved by the institutional review board of Zhejiang University School of Medicine and Zhoushan Maternal and Child Care Hospital.

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Mao, Y., Wang, S., Li, M. et al. Association of trimester-specific gestational weight gain with birth weight and fetal growth in a large community-based population. Arch Gynecol Obstet 300, 313–322 (2019). https://doi.org/10.1007/s00404-019-05188-8

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  • DOI: https://doi.org/10.1007/s00404-019-05188-8

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