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Type-II endometrial cancer: role of adipokines

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Abstract

Background

Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, which was clinically evidenced.

Areas covered

This review presents the role of various adipokines involved and also the suitable modulators to treat Type-II endometrial cancer.

Conclusion

In the present review, we try to discuss the role of individual adipokines in the pathogenesis of Type-II endometrial cancer, and also the possible beneficial effects of adipokines modulator in the treatment of Type-II endometrial cancer.

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  1. Department of Pharmacology, JSS College of Pharmacy (A Constituent College of JSS Academy of Higher Education & Research), Ooty, Tamil Nadu, 643001, India

    Kusuma Kumari Garikapati, V. V. V. Ravi Kiran Ammu, Praveen T. Krishnamurthy, Pavan Kumar Chintamaneni & Sai Kiran S. S. Pindiprolu

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  1. Kusuma Kumari Garikapati
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  2. V. V. V. Ravi Kiran Ammu
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  3. Praveen T. Krishnamurthy
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  4. Pavan Kumar Chintamaneni
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  5. Sai Kiran S. S. Pindiprolu
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Correspondence to Praveen T. Krishnamurthy.

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The first author Garikapati Kusuma Kumari declares that she has no conflict of interest. The second author A. V. V. V. Ravi Kiran declares that he has no conflict of interest. The third author and corresponding author Dr. Praveen T. K declares that he has no conflict of interest. The fourth author Pavan Kumar Chintamaneni declares that he has no conflict of interest. The fifth author Sai Kiran S. S. Pindiprolu declares that he has no conflict of interest.

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Garikapati, K.K., Ammu, V.V.V.R.K., Krishnamurthy, P.T. et al. Type-II endometrial cancer: role of adipokines. Arch Gynecol Obstet 300, 239–249 (2019). https://doi.org/10.1007/s00404-019-05181-1

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