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Wnt signaling pathway in early- and late-onset preeclampsia: evaluation with Dickkopf-1 and R-Spondin-3 glycoproteins

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

Wnt signaling has been identified as an essential pathway that can direct cell proliferation, migration, and tissue homeostasis. This study aimed to evaluate the role of Wnt signaling pathway in early-onset and late-onset preeclampsia (PE) using serum Dickkopf-1 and R-Spondin-3 glycoproteins.

Study design

A total of 80 pregnant women were included in this study. The patients were divided into three groups: (1) control (2) early-onset PE, and (3) late-onset PE. The serum levels of Dickkopf-1 and R-Spondin-3 were measured using an enzyme-linked immunosorbent assay.

Results

Of the 80 pregnant women enrolled in the study, 27 were control, 27 had early-onset PE, and 26 had late-onset PE. No differences were found in the maternal age, gravida, parity, and body mass index among the groups (P = 0.536, 0.230, 0.202, and 0.642, respectively). The serum level of Dickkopf-1 was significantly higher in the early-onset PE group compared with the control group (P = 0.006). The serum level of Dickkopf-1 was statistically similar in control group compared to late-onset PE group (P = 0.064). However, no significant difference was found in the serum levels of Dickkopf-1 and R-Spondin-3 between the early- and late-onset PE groups (P > 0.05). Additionally, the Spearman’s correlation analysis revealed a significant negative correlation between maternal serum level of Dickkopf-1 and maternal age (r = − 0.522, P = 0.005).

Conclusion

The increased serum level of Dickkopf-1 might be associated with the process of pathogenesis of early-onset PE. Further studies would elucidate their exact roles in the pathogenesis of PE.

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Funding

This study did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Acıbadem University Medical Faculty Maslak Acıbadem Hospital, Istanbul, Turkey

    Ahter Tanay Tayyar

  2. Department of Obstetrics and Gynecology, Zeynep Kamil Maternity and Children’s Training and Research Hospital, Health Sciences University, Istanbul, Turkey

    Resul Karakus, Seren Karakus & Emel Tugce Yalcın

  3. Department of Obstetrics and Gynecology, Sivas Sarkisla Government Hospital, Sivas, Turkey

    Mefkure Eraslan Sahin & Erdem Sahin

  4. Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Education and Research Hospital, Health Sciences University, Istanbul, Turkey

    Nura Fitnat Topbas

  5. Department of Obstetrics and Gynecology, Medipol University Medical Faculty, Istanbul, Turkey

    Ahmet Tayyar

Authors
  1. Ahter Tanay Tayyar
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  2. Resul Karakus
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  3. Mefkure Eraslan Sahin
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  4. Nura Fitnat Topbas
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  5. Erdem Sahin
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  6. Seren Karakus
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  7. Emel Tugce Yalcın
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  8. Ahmet Tayyar
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Contributions

ATT, AT, RK: project development. NFT, SK, ETY: data collection management and data analysis. MES, ES: manuscript writing and editing.

Corresponding author

Correspondence to Mefkure Eraslan Sahin.

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The authors declare no conflicts of interest in regard to this study.

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Tayyar, A.T., Karakus, R., Eraslan Sahin, M. et al. Wnt signaling pathway in early- and late-onset preeclampsia: evaluation with Dickkopf-1 and R-Spondin-3 glycoproteins. Arch Gynecol Obstet 299, 1551–1556 (2019). https://doi.org/10.1007/s00404-019-05126-8

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  • DOI: https://doi.org/10.1007/s00404-019-05126-8

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