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Ruptured renal artery aneurysm in pregnancy and puerperium: literature review of 53 cases

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Abstract

Purpose

To summarize and define the most appropriate diagnostic methods and therapeutic options for ruptured renal artery aneurysms in pregnancy based on rarely published data.

Methods

Literature searches of English-, German-, Spanish-, and Italian-language articles were performed in PubMed (1946–2018), PubMed Central (1900–2018) and Google Scholar. The search terms included renal artery aneurysm, renal artery rupture, pregnancy, puerperium, nierenarterienaneurysma, schwangerschaft, wochenbett, aneurisma de la arteria renal, el embarazo, puerperio, aneurisma dell'arteria renale and gravidanza. Additional studies were identified by reviewing reference lists of retrieved studies.

Results

Fifty-three cases were collected. The average maternal age was 31 ± 6 years; 71.4% were multiparous and significantly older than primiparas. The majority presented in the third trimester (62.3%), followed by second (20.7%) and the first (5.7%), while 11.3% presented postpartum. All postpartum patients presented during the first week postpartum and 50% during the first 24 h postpartum. Parity was not associated with the trimester of presentation. The left renal artery was affected slightly more frequently (58.5% vs. 41.5%). There were no differences in the affected side according to trimester of presentation, including postpartum. 25 out of 53 cases underwent ipsilateral nephrectomy (47.1%) and 18 underwent aneurysm repair or coil embolization (34.0%). There was no difference in maternal (25.8%) vs. 4 (18.1%) and fetal mortality according to the side of rupture. There were no differences in the distribution of maternal or fetal mortality frequency according to the trimester of presentation.

Conclusions

The clinical presentation is easily confused with more common conditions and time to diagnosis is often delayed. Diagnostic delay is associated with high maternal and fetal mortality. Ruptured renal artery aneurysm should be included in the differential diagnosis for pregnant or peripartum patients presenting with acute and severe flank pain, especially if followed by a drop in blood pressure. Early diagnosis and immediate intervention are important for achieving better maternal and fetal outcomes. There are several methods of managing asymptomatic or ruptured renal artery aneurysm during pregnancy although no established guidelines exist.

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Authors and Affiliations

  1. Department of Surgery, University Hospital Centre Zagreb and School of Medicine University of Zagreb, Kišpatićeva 12, 10000, Zagreb, Croatia

    Goran Augustin

  2. Department of Urology, University Hospital Centre Zagreb and School of Medicine University of Zagreb, Kišpatićeva 12, 10000, Zagreb, Croatia

    Tomislav Kulis

  3. Division of Rheumatology, Northwell Health, 865 Northern Boulevard, Great Neck, NY, 11021, USA

    Nina Kello

  4. Department of Internal Medicine, University Hospital Centre Zagreb and School of Medicine University of Zagreb, Kišpatićeva 12, 10000, Zagreb, Croatia

    Vanja Ivkovic

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  1. Goran Augustin
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  2. Tomislav Kulis
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  3. Nina Kello
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  4. Vanja Ivkovic
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GA: data collection, data analysis, manuscript writing. TK and VI: data collection and data analysis. NK: manuscript writing, supervision.

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Correspondence to Goran Augustin.

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Augustin, G., Kulis, T., Kello, N. et al. Ruptured renal artery aneurysm in pregnancy and puerperium: literature review of 53 cases. Arch Gynecol Obstet 299, 923–931 (2019). https://doi.org/10.1007/s00404-019-05087-y

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