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A prospective cohort study on the prediction of the diagnosis-to-delivery time in preeclamptic pregnancies: should the sFlt-1/PlGF ratio be added to routine evaluations?

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To analyze the clinical and laboratory factors that potentially affect the diagnosis-to-delivery time in preeclamptic pregnancies.

Methods

In this cross-sectional study, we followed 24 early onset preeclampsia (E-PE) and 26 late-onset preeclampsia (L-PE) cases. Maternal serum samples were obtained at the time of diagnosis and stored at − 80 °C until ELISA analysis for soluble fms-like tyrosine kinase-1 (SFlt-1) and placental growth factor (PlGF) levels.

Results

The median follow-up duration was 68 (1–339) h in the E-PE group and 330 (7–1344) h in the L-PE group. Maternal mean arterial pressure (MAP) at hospitalization was the strongest variable, and the sFlt-1/PlGF ratio added significantly to the Cox regression model. In the E-PE cases, the median sFlt-1/PlGF ratio was significantly higher in the subgroup with a follow-up duration > 48 h than in the subgroup of cases with a follow-up duration ≤ 48 h (5109 vs. 2080; p = 0.038), and none of the seven cases with an sFlt-1/PlGF ratio ≥ 75th percentile delivered during the first 48 h. Neither the 24-h proteinuria nor the gestational age at diagnosis added to the predictive power of the MAP at hospitalization.

Conclusion

Incorporation of the sFlt-1/PlGF ratio to the routine evaluation of preeclamptic pregnancies may help in the prediction of progression and management planning.

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Funding

This research was supported by a grant from Dokuz Eylul University Scientific Research Projects Coordination Unit.

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Authors and Affiliations

  1. Division of Perinatology, Department of Obstetrics and Gynecology, Dokuz Eylul University School of Medicine, Balcova, 35340, Izmir, Turkey

    Semir Kose, Gülnar Nuriyeva, Sabahattin Altunyurt & Omer Erbil Doğan

  2. Department of Molecular Medicine, Dokuz Eylul University Institute of Health Sciences, Balcova, 35340, Izmir, Turkey

    Gamze Tuna

  3. Department of Medical Biochemistry, Dokuz Eylul University School of Medicine, Balcova, 35340, Izmir, Turkey

    Gül Hüray Islekel

Authors
  1. Semir Kose
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  2. Gamze Tuna
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  3. Gülnar Nuriyeva
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  4. Sabahattin Altunyurt
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  5. Gül Hüray Islekel
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  6. Omer Erbil Doğan
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Contributions

SK: involved in protocol development, data collection, data analysis, and manuscript writing; GT: laboratory analysis and data collection; GN: protocol development and data collection; SA: protocol development and manuscript editing; GHI: laboratory analysis and manuscript editing; OED: protocol development and manuscript editing.

Corresponding author

Correspondence to Semir Kose.

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The authors declare that they have no conflicts of interest.

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Kose, S., Tuna, G., Nuriyeva, G. et al. A prospective cohort study on the prediction of the diagnosis-to-delivery time in preeclamptic pregnancies: should the sFlt-1/PlGF ratio be added to routine evaluations?. Arch Gynecol Obstet 298, 911–920 (2018). https://doi.org/10.1007/s00404-018-4903-5

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  • DOI: https://doi.org/10.1007/s00404-018-4903-5

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