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Physical plasma: a new treatment option in gynecological oncology

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Abstract

Non-thermal application of physical plasma is rapidly gaining importance for the future therapy and prevention of chronic inflammatory diseases and tumors. Here, we outline the importance of this innovative and less invasive therapy option, particulary for the treatment and prevention of gynecological cancers.

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References

  1. Moisan M, Barbeau J, Moreau S, Pelletier J, Tabrizian M, Yahia LH (2001) Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms. Int J Pharm 226:1–21

    Article  CAS  PubMed  Google Scholar 

  2. Bekeschus S, Kolata J, Winterbourn C, Kramer A, Turner R, Weltmann KD, Bröker B, Masur K (2014) Hydrogen peroxide: a central player in physical plasma-induced oxidative stress in human blood cells. Free Radic Res 48:542–549

    Article  CAS  PubMed  Google Scholar 

  3. Kieft IE, Broers JL, Caubet-Hilloutou V, Slaaf DW, Ramaekers FC, Stoffels E (2004) Electric discharge plasmas influence attachment of cultured CHOK1 cells. Bioelectromagnetics 25:362–368

    Article  CAS  PubMed  Google Scholar 

  4. Kieft IE, Darios D, Roks AJM, Stoffels E (2005) Plasma treatment of mammalian vascular cells: a quantitative description. IEEE Trans Plasma Sci 33:771–775

    Article  Google Scholar 

  5. Stoffels E, Kieft IE, Sladek REJ, Bedem LJM, Laan EP, Steinbuch M (2006) Plasma needle for in vivo medical treatment: recent developments and perspectives. Plasma Sources Sci Technol 15:169–180

    Article  CAS  Google Scholar 

  6. Stoffels E, Roks AJM, Deelman LE (2008) Delayed effects of cold atmospheric plasma on vascular cells. Plasma Processes Polym 5:599–605

    Article  CAS  Google Scholar 

  7. Dubuc A, Monsarrat P, Virard F, Merbahi N, Sarrette JP, Laurencin-Dalicieux S, Cousty S (2018) Use of cold-atmospheric plasma in oncology: a concise systematic review. Ther Adv Med Oncol 10:1758835918786475

    Article  PubMed Central  PubMed  Google Scholar 

  8. Fridman G, Shereshevsky A, Jost M, Brooks A, Fridman A, Gutsol A, Vasilets V, Friedman G (2007) Floating electrode dielectric barrier discharge plasma in air promoting apoptotic behavior in melanoma skin cancer cell lines. Plasma Chem Plasma Process 27:163–176

    Article  CAS  Google Scholar 

  9. Kanduc D, Mittelman A, Serpico R, Sinigaglia E, Sinha AA, Natale C, Santacroce R, Di Corcia MG, Lucchese A, Dini L, Pani P, Santacroce S, Simone S, Bucci R, Farber E (2002) Cell death: apoptosis versus necrosis (review). Int J Oncol 21:165–170

    CAS  PubMed  Google Scholar 

  10. Kluge S, Bekeschus S, Bender C, Benkhai H, Sckell A, Below H, Stope MB, Kramer A (2016) Investigating the mutagenicity of a cold argon-plasma jet in an HET-MN model. PLoS One 11:e0160667

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Wende K, Bekeschus S, Schmidt A, Jatsch L, Hasse S, Weltmann KD, Masur K, von Woedtke T (2016) Risk assessment of a cold argon plasma jet in respect to its mutagenicity. Mutat Res, Genet Toxicol Environ Mutagen 798:48–54

    Article  CAS  Google Scholar 

  12. Welz C, Emmert S, Canis M, Becker S, Baumeister P, Shimizu T, Morfill GE, Harréus U, Zimmermann JL (2015) Cold atmospheric plasma: a promising complementary therapy for squamous head and neck cancer. PLoS One 10:e0141827

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Lee S, Lee H, Jeong D, Ham J, Park S, Choi EH, Kim SJ (2017) Cold atmospheric plasma restores tamoxifen sensitivity in resistant MCF-7 breast cancer cells. Free Radic Biol Med 110:280–290

    Article  CAS  PubMed  Google Scholar 

  14. Wang M, Holmes B, Cheng X, Zhu W, Keidar M, Zhang LG (2013) Cold atmospheric plasma for selectively ablating metastatic breast cancer cells. PLoS One 8:e73741

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Jalili A, Irani S, Mirfakhraie R (2016) Combination of cold atmospheric plasma and iron nanoparticles in breast cancer: gene expression and apoptosis study. Onco Targets Ther 9:5911–5917

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Ishikawa K, Kondo H, Kano H, Hori M, Kikkawa F (2013) Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo. PLoS One 8:e81576

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Hori M, Kikkawa F (2014) Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma. Springerplus 3:398

    Article  PubMed Central  PubMed  Google Scholar 

  18. Koensgen D, Besic I, Gümbel D, Kaul A, Weiss M, Diesing K, Kramer A, Bekeschus S, Mustea A, Stope MB (2017) Cold atmospheric plasma (CAP) and CAP-stimulated cell culture media suppress ovarian cancer cell growth—a putative treatment option in ovarian cancer therapy. Anticancer Res 37:6739–6744

    PubMed  Google Scholar 

  19. Ahn HJ, Kim KI, Kim G, Moon E, Yang SS, Lee JS (2011) Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals. PLoS One 6:e28154

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Li Y, Ho Kang M, Sup Uhm H, Joon Lee G, Ha Choi E, Han I (2017) Effects of atmospheric-pressure non-thermal bio-compatible plasma and plasma activated nitric oxide water on cervical cancer cells. Sci Rep 7:45781

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Partecke LI, Evert K, Haugk J, Doering F, Normann L, Diedrich S, Weiss FU, Evert M, Huebner NO, Guenther C, Heidecke CD, Kramer A, Bussiahn R, Weltmann KD, Pati O, Bender C, von Bernstorff W (2012) Tissue tolerable plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo. BMC Cancer 12:473

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Kawasaki T, Sato A, Kusumegi K, Kudo A, Sakanoshita T, Tsurumaru T, Uchida G, Koga K, Shiratani M (2016) Two-dimensional concentration distribution of reactive oxygen species transported through a tissue phantom by atmospheric-pressure plasma-jet irradiation. Appl Phys Express 9:076202

    Article  CAS  Google Scholar 

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Funding

This work was supported by the Faculty of Medicine of the Eberhard Karls University Tübingen (Grant No. 2432-1-0).

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M Weiss and MB Stope equally contributed to conceptualization, project administration, writing/editing of the manuscript.

Corresponding author

Correspondence to Martin Weiss.

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We declare that we have no conflict of interest.

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Weiss, M., Stope, M.B. Physical plasma: a new treatment option in gynecological oncology. Arch Gynecol Obstet 298, 853–855 (2018). https://doi.org/10.1007/s00404-018-4889-z

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  • DOI: https://doi.org/10.1007/s00404-018-4889-z

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