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Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials

Abstract

Purpose

To evaluate whether oral myo-inositol supplementation (MI) is able to reduce the amount of gonadotropins (GA) and the length of controlled ovarian hyperstimulation (SL) in both Polycystic Ovarian Syndrome (PCOS) and non-PCOS women undergoing in vitro fertilization (IVF).

Methods

We performed a systematic review (PROSPERO ID: CRD42017069439) of randomized controlled trials (RCTs). We searched articles published in English between January 1985 to August 2017, using the combination of the Medical Subject Headings “Inositol” with “Ovulation Induction”, “follicle-stimulating hormone, human, with HCG C-terminal peptide”, “Reproductive Techniques, Assisted”, and “Fertilization in Vitro”. We collected data about GA and SL comparing MI to no treatment or d-Chiro-Inositol (DCI) supplementation (controls). A subgroup analysis was performed to evaluate selected outcomes in PCOS and non-PCOS women.

Results

We included 8 studies embedding 812 participants. We found a reduction in GA (p < 0.00001) and SL (p = 0.0007) in patients receiving MI with respect to controls. MI was effective in both PCOS (p < 0.00001) and non-PCOS women (p = 0.02) in reducing GA; conversely, MI supplementation decreased the SL only in PCOS women (p < 0.00001).

Conclusion

During IVF, MI is effective in both PCOS and non-PCOS women in saving gonadotropins, but reduces efficiently SL only in PCOS women.

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Funding

The work was not supported by any grant/fund.

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Authors and Affiliations

Authors

Contributions

ASL: designed the systematic review and lead its development. AV and MN: performed the meta-analysis of retrieved data. GA: edited the manuscript. RD: supervised the development of the systematic review and meta-analysis and gave the final approval. All the authors concurred to screen the literature, include relevant data and write the manuscript. All the authors fulfil the International Committee of Medical Journal Editors (ICMJE) criteria.

Corresponding author

Correspondence to Antonio Simone Laganà.

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The authors have no proprietary, financial, professional, or other personal interest of any nature in any product, service, or company. The authors alone are responsible for the content and writing of the paper.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Laganà, A.S., Vitagliano, A., Noventa, M. et al. Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials. Arch Gynecol Obstet 298, 675–684 (2018). https://doi.org/10.1007/s00404-018-4861-y

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Keywords

  • Myo-inositol
  • In vitro fertilization
  • Recombinant follicle-stimulating hormone
  • Controlled ovarian hyperstimulation