Archives of Gynecology and Obstetrics

, Volume 297, Issue 5, pp 1339–1341 | Cite as

RE: Pathobiology of myomatosis uteri: the underlying knowledge to support our clinical practice

  • Yeon-Suk Kim
  • Tae-Hee Kim
  • Hae-Hyeog Lee
  • Kisung Song

Dear Editor,

We have read the review article by Roche et al. reporting clinical evidence of the pathobiology of uterine myomatosis [1]. There is no question that the pathobiology of myomatosis uteri is multifactorial and includes genetic factors, epigenetic factors, growth factors, sexual hormones, angiogenesis, and proinflammatory mediators. This review aids in our understanding of the mechanisms of uterine myomatosis.

Meticulous patient-centered pathobiological information is needed to help physicians better understand the pathological mechanisms of leiomyoma. Specifically, genetic testing is an important issue in all clinical fields, including genetic counseling [2]. At present, high-resolution sequencing data can be generated in less time and at a lower cost than ever before using next-generation sequencing technologies. Our understanding of the genetics of tumor types has deepened remarkably with the emergence of next-generation sequencing technologies [3]. Next-generation...



This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1D1A3A01018104).

Author contribution

YS Kim: Manuscript writing, Data management. Giving important intellectual content. TH Kim: Conception and design. Manuscript editing. HH Lee: Giving important intellectual content, Final approval of the version to be submitted. KS Song: Data collection.

Compliance with ethical standards

Conflict of interest statement

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All procedures were conducted using protocols approved by the ethics committee of Soonchunhyang University Bucheon Hospital.

Informed consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Torres-de la Roche LA, Becker S, Cezar C, Hermann A, Larbig A, Leicher L, Di Spiezio Sardo A, Tanos V, Wallwiener M, Verhoeven H, De Wilde RL (2017) Pathobiology of myomatosis uteri: the underlying knowledge to support our clinical practice. Arch Gynecol Obstet. PubMedGoogle Scholar
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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Interdisciplinary Program in Biomedical ScienceSoonchunhyang University Graduate SchoolAsanRepublic of Korea
  2. 2.Department of Obstetrics and Gynecology, Soonchunhyang University College of MedicineSoonchunhyang University Bucheon HospitalBucheon-SiRepublic of Korea

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