Pregnancy-associated complications, duration of gestation and parity are well-known predictors of neonatal birth weight. Assisted reproductive technology (ART) affects neonatal birth weight as well. Endometrial thickness as measured on the day of HCG triggering may therefore impact on the neonatal birth weight.
The data of 764 singleton deliveries achieved after fresh transfer between November 1997 and 2014 were collected retrospectively with the intention to analyze the relationship of maternal and neonatal characteristics with endometrial thickness and the possible predictive value of endometrial thickness on neonatal birth weight.
Higher maternal age (p < 0.001), diminished ovarian reserve (p < 0.001), endometriosis (p = 0.008) and hypogonadotropic hypogonadism (p < 0.001) predicted thin endometrium. Neonatal birth weight (p = 0.004), longer duration of pregnancy (p = 0.008), parity (p = 0.026) and higher maternal BMI (p = 0.003) were correlated significantly with the degree of endometrial proliferation. Endometrial thickness strongly predicted neonatal birth weight (p = 0.004). After adjusting regression analysis for maternal age and BMI, parity, neonatal gender and pregnancy duration, endometrial thickness remained predictive for neonatal birth weight in pregnancies with obstetric complications (p = 0.017). In uneventful pregnancies duration and parity are determinants of neonatal birth weight.
Our findings suggest that endometrial thickness is an additional ART-related factor influencing neonatal birth weight. This finding should be confirmed in large cohort studies.
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RM was awarded an exchange grant to the Université Paris Descartes, France, by the University of Basel, Switzerland. This study was also supported by the Repronatal Foundation, Basel, Switzerland.
Conflict of interest
All authors declare that they have no conflict of interest.
The study protocol was approved by the institutional ethics committee.
According to Swiss legislation informed consent must not be obtained for retrospective data analysis if it is disproportionately difficult to obtain consent and the interests of research outweigh the interests of the person concerned.
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Moffat, R., Beutler, S., Schötzau, A. et al. Endometrial thickness influences neonatal birth weight in pregnancies with obstetric complications achieved after fresh IVF–ICSI cycles. Arch Gynecol Obstet 296, 115–122 (2017). https://doi.org/10.1007/s00404-017-4411-z
- Endometrial thickness
- Neonatal birth weight
- Assisted reproduction
- Ovarian hyperstimulation
- Obstetrical outcome