Archives of Gynecology and Obstetrics

, Volume 296, Issue 2, pp 277–283 | Cite as

Comparison of the effect of honey and mefenamic acid on the severity of pain in women with primary dysmenorrhea

  • Ë Leila Amiri Farahani
  • Seyedeh Batool Hasanpoor-Azghdy
  • Hengameh Kasraei
  • Tooba Heidari
General Gynecology


Background and objective

Primary dysmenorrhea starts simultaneously with menstruation or before it and usually continues for 48–72 h. As a prevalence disorder, it affects about 80–97% of women in the reproductive age. The conventional treatment modalities of primary dysmenorrhea are associated with complications and side effects. In addition, there is a lack of knowledge of the effect of honey on the treatment of primary dysmenorrhea. The objective of this study is to investigate the effect of honey on the severity of pain in women with dysmenorrhea.


A randomized crossover clinical trial was conducted on 56 female students. Subjects were randomly assigned to two groups. Groups I and II received honey and mefenamic acid in the ‘first treatment period’, respectively. In the ‘second treatment period’, the intervention methods were reversed between the groups. Samples recorded the severity of pain during the first 3 days of menstruation.


There were no significant differences in the most severe level of pain in the first and second months of the first treatment period, and the first and second months of the second treatment period between the groups.


Honey and the mefenamic acid capsules led to the same amount of pain relief in women with primary dysmenorrhea. Honey is suggested to be used for pain relief due to its lower side effects and pharmacological complications.


Honey Mefenamic acid Primary dysmenorrhea Women 


  1. 1.
    Ju H, Jones M, Mishra G (2013) The prevalence and risk factors of dysmenorrhea. Epidemiol Rev 26:mxt009Google Scholar
  2. 2.
    Nevatte T, O’Brien PM, Bäckström T, Brown C, Dennerstein L, Endicott J, Epperson CN, Eriksson E, Freeman EW, Halbreich U, Ismail K (2013) ISPMD consensus on the management of premenstrual disorders. Arch Women’s Mental Health 16(4):279–291CrossRefGoogle Scholar
  3. 3.
    Berek JS (2011) Berek and Novak’s gynecology, 15th edn. Lippincott, New YorkGoogle Scholar
  4. 4.
    Ryan KJ (ed) (1999) Kistner’s gynecology and women’s health. Mosby Inc, St. LouisGoogle Scholar
  5. 5.
    Durain D (2004) Primary dysmenorrhea: assessment and management update. J Midwifery Women’s Health 49(6):520–528CrossRefGoogle Scholar
  6. 6.
    Polat A, Celik H, Gurates B, Kaya D, Nalbant M, Kavak E, Hanay F (2009) Prevalence of primary dysmenorrhea in young adult female university students. Arch Gynecol Obstet 279(4):527–532CrossRefPubMedGoogle Scholar
  7. 7.
    Fattahi Bafghi A, Yavari M, Hossein Zadeh J (2007) Usefullness of honey from the Islamic point of view and evaluation of its effects on cutaneous leishmaniasis wounds in Balb/C rats invitro. SSU_Journals 14(4):32–36Google Scholar
  8. 8.
    Sobhanian S, Purahmad M, Modaber M, Pishe SG, Adineh B (2006) Effect of natural honey on diabetic leg sore. J Tehran Fac Med 4(64):108–110Google Scholar
  9. 9.
    Al-Waili NS (2005) Effects of honey on the urinary total nitrite and prostaglandins concentration. Int Urol Nephrol 37(1):107–111CrossRefPubMedGoogle Scholar
  10. 10.
    Al-Waili NS, Boni NS (2003) Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food 6(2):129–133CrossRefPubMedGoogle Scholar
  11. 11.
    Mirbagher Ajorpaz N, Hafezi M, Salehi S, Tayebi A, Shenasa F, Zahtabchi S (2012) Comparing the effect of pure and impure honey on severity of pain, amount of bleeding, and duration and interval of menstrual cycles in female students with primary dysmenorrhea. Evid Based Care 2(1):23–33Google Scholar
  12. 12.
    Direkvand-Moghadam A, Khosravi A (2012) Comparison of verbal multidimensional scoring system (VMS) with visual analogue score (VAS) for evaluating of Shirazi thymus vulgaris on menstrual pain. J Pharm Biomed Sci (JPBMS) 23(23):1–5Google Scholar
  13. 13.
    Unsal A, Ayranci U, Tozun M, Arslan G, Calik E (2010) Prevalence of dysmenorrhea and its effect on quality of life among a group of female university students. Upsala J Med Sci 115(2):138–145CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Gift AG (1989) Visual analogue scales: measurement of subjective phenomena. Nurs Res 38(5):286–287CrossRefPubMedGoogle Scholar
  15. 15.
    Wewers ME, Lowe NK (1990) A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health 13(4):227–236CrossRefPubMedGoogle Scholar
  16. 16.
    Shirvani MA, Motahari-Tabari N, Alipour A (2015) The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet 291(6):1277–1281CrossRefPubMedGoogle Scholar
  17. 17.
    Nahid K, Fariborz M, Ataolah G, Solokian S (2009) The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Women’s Health 54(5):401–404CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Midwifery, School of Nursing and MidwiferyArak University of Medical SciencesArakIran
  2. 2.Department of Reproductive Health and Midwifery, School of Nursing and MidwiferyIran University of Medical SciencesTehranIran
  3. 3.Student Research CommitteeShiraz University of Medical SciencesShirazIran
  4. 4.School of MedicineInternational Branch, Shiraz University of Medical SciencesShirazIran

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