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Serum serotonin, leptin, and adiponectin changes in women with postpartum depression: controlled study

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Postpartum depression (PPD) affects nearly 10% of mothers after delivery and has many serious results. Although many factors associated with PPD, the etiology, and pathophysiology of PPD are not known completely. The relationship between serum serotonin concentration and depression is well known, but there are no enough data regarding the serum change of leptin and adiponectin. The aims of this study are to research the level of serum serotonin, leptin,s and adiponectin concentrations in women with PPD.

Materials and methods

A controlled trial has been conducted in three centers. Two hundred and forty four women were evaluated at postpartum day 10 with the Edinburgh Postnatal Depression Scale (EPDD). Venous blood samples were collected and serotonin, and leptin and adiponectin levels were studied using human enzyme-linked immunosorbent assay. Mann–Whitney U test was used for comparison of serum levels of serotonin, leptin, and adiponectin between women with PPD and without. A p value of <0.05 was considered significant.

Results

PPD was detected in 70 postpartum women. The mean serum serotonin level was significantly lower in the group with PPD (p = 0.001), while mean serum adiponectin level was higher (p = 0.001). The mean serum leptin level was not different (p = 0.133).

Conclusions

The serum adiponectin and leptin levels were high in women with PPD. This could play important role in the pathophysiology of PPD. Elevation of serum levels also may play antidepressant role against PPD, especially the early postpartum period.

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Acknowledgements

There is no financial relationship with any biotechnology manufacturer, any pharmaceutical company, or other commercial entity that has an interest in the subject matter or materials discussed in the manuscript. The study was registered on clinical trials.gov with No NCT02682004.

Author contrıbutıon statement

GY: Data collection. MBS: Project development, manuscript writing. PY: Data collection. YC: Data collection. MSB: Literature reviewing. EC: Literature reviewing, statistical analysis.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Muş Şifa Private Hospital, Kültür district, 168 th street, Muş, Turkey

    Gazi Yildiz & Pinar Yildiz

  2. Department of Obstetrics and Gynecology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, Opr. Dr. Burhanettin Ustunel street, No: 10, 34668, Uskudar, Istanbul, Turkey

    Mehmet Baki Senturk & Erbil Cakar

  3. Department of Obstetrics and Gynecology, Batman State Hospital, Ziya Gokalp district, 72060, Batman, Turkey

    Yusuf Cakmak

  4. Department of Obstetrics and Gynecology, Diyarbakir Women and Child Hospital, Bagcılar district, 21060, Baglar, Diyarbakir, Turkey

    Mehmet Sukru Budak

Authors
  1. Gazi Yildiz
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  2. Mehmet Baki Senturk
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  3. Pinar Yildiz
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  4. Yusuf Cakmak
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  6. Erbil Cakar
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Corresponding author

Correspondence to Mehmet Baki Senturk.

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Funding

This study was not supported by any company or institution.

Conflict of interest

The authors declared that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The design of the study was approved by the local ethics committee of Zeynep Kamil Training and Research Hospital with No. 51.

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Yildiz, G., Senturk, M.B., Yildiz, P. et al. Serum serotonin, leptin, and adiponectin changes in women with postpartum depression: controlled study. Arch Gynecol Obstet 295, 853–858 (2017). https://doi.org/10.1007/s00404-017-4313-0

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  • DOI: https://doi.org/10.1007/s00404-017-4313-0

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