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Preterm delivery and future maternal risk of female malignancies

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To investigate whether an association exists between preterm delivery and a future risk for female malignancies.

Methods

A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of PTD. Deliveries occurred between the years 1988–2013, with a mean follow-up duration of 12 years. We excluded women with known genetic predisposition or malignancies prior to the index pregnancy. Malignancies investigated included ovarian, uterine, breast and cervix. Cumulative incidence was assessed using a Kaplan–Meier survival curve. A Cox proportional hazards model was used to estimate the adjusted hazard ratios (HR) for female malignancy.

Results

During the study period, 105,033 women met the inclusion criteria; 16.8 % (n = 17,596) of the patients delivered preterm. Patients with a history of PTD did not have an increased risk of later being diagnosed with female malignancies. The results remained insignificant in a sub-analysis based on malignancy type, early PTD, induced vs. spontaneous, and number of episodes per patient. Kaplan–Meier cumulative incidence was similar between the groups, and the adjusted HR was not significant (1.04, 95 % CI 0.88–1.22; p = 0.665).

Conclusion

A history of PTD does not appear to elevate the risk for subsequent long-term female malignancies.

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, POB 151, Beer Sheva, 84101, Israel

    Roy Kessous, Asnat Walfisch, Mihai Meirovitz & Eyal Sheiner

  2. Faculty of Health Sciences, Soroka University Medical Center, Clalit Health Services (Southern District), Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Ehud Davidson

  3. Department of Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Ruslan Sergienko

Authors
  1. Roy Kessous
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  2. Asnat Walfisch
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  3. Mihai Meirovitz
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  4. Ehud Davidson
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  5. Ruslan Sergienko
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  6. Eyal Sheiner
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Corresponding author

Correspondence to Asnat Walfisch.

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Conflict of interest

All authors declare that no authors (nor their institutions) received payments for their efforts on this project. The authors report no conflict of interest.

Ethics approval

The study was approved by the institutional review board of Soroka University Medical Center. For this type of study—population-based cohort study—formal consent is not required.

Funding

This study was not funded.

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Cite this article

Kessous, R., Walfisch, A., Meirovitz, M. et al. Preterm delivery and future maternal risk of female malignancies. Arch Gynecol Obstet 295, 205–210 (2017). https://doi.org/10.1007/s00404-016-4198-3

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  • DOI: https://doi.org/10.1007/s00404-016-4198-3

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