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Binge eating and biochemical markers of appetite in new users of the contraceptive depot medroxyprogesterone acetate



Weight gain has been cited by women as one of the main reasons for discontinuation of the contraceptive depot medroxyprogesterone acetate (DMPA). This study aimed to evaluate binge eating and the biochemical markers of appetite in new DMPA users.


In this prospective non randomized study with adult healthy women, twenty-eight users of DMPA and twenty-five users of a copper intrauterine device (IUD) were paired for age (±1 year) and body mass index (BMI) (±1 kg/m2). We evaluated binge eating using the Binge Eating Scale (BES), the serum levels of neuropeptide Y, leptin and adiponectin, and the BMI at baseline and after 12 months in both groups. For statistical analysis was used ANOVA for to compare the means of the repeated measurements.


Mean age was 29.6 and 28.6 years and BMI was 23.9 and 24.5 kg/m2 for the DMPA and IUD groups, respectively. After 12 months, the frequency of the scores of binge eating remained low in both groups. There were no significant differences between the groups at 12 months with respect to BMI, levels of NPY, leptin, adiponectin, and BES scores.


Healthy adult women did not present with central stimulation of appetite or binge eating disorder in their first year after starting use of DMPA. This study reinforces the use of the contraceptive DPMA and the need for guidance related to living a healthy lifestyle for women who attribute the increase of body weight to the use of the method.

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São Paulo Research Foundation (FAPESP), Grant #2011/14827-9 and CAPES (Coordination for the Improvement of Higher Education Personnel) through a Grant conceded to PNSS. The original study was funded by the Brazilian National Research Council (CNPq) and by the Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP), Secretaria de Estado da Saúde de São Paulo (SES-SP) Grant PPSUS/2009, #2009/53293-0, Brazil. The authors claim they have not a financial relationship with the organization that sponsored the research. We claim that we have had full control of all primary data and that we agree to allow the Journal to review their data if requested.

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Correspondence to Arlete Fernandes.

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The authors declare that they have no conflict of interest. The authors alone are responsible for the content and the writing of the paper.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Silva dos Santos, P.d., de Souza, A.L., Batista, G.A. et al. Binge eating and biochemical markers of appetite in new users of the contraceptive depot medroxyprogesterone acetate. Arch Gynecol Obstet 294, 1331–1336 (2016).

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  • Depot medroxyprogesterone acetate
  • Contraception
  • NPY
  • Appetite
  • Eating disorder