Archives of Gynecology and Obstetrics

, Volume 294, Issue 4, pp 841–846 | Cite as

Fractional CO2 laser for vulvovaginal atrophy (VVA) dyspareunia relief in breast cancer survivors

  • Annalisa PieralliEmail author
  • Maria Grazia Fallani
  • Angelamaria Becorpi
  • Claudia Bianchi
  • Serena Corioni
  • Manuela Longinotti
  • Zelinda Tredici
  • Secondo Guaschino
Gynecologic Oncology



The aim of this study was to evaluate the efficacy of fractional CO2 laser therapy in breast cancer survivors as a therapeutic method for vulvovaginal atrophy (VVA) dyspareunia.


50 patients (mean age 53.3 years) underwent fractional microablative CO2 laser treatment for dyspareunia in oncological menopause (mean time of menopause 6.6 years). The Gloria Bachmann’s Vaginal Health Index (VHI) score was chosen as system to evaluate the presence of VVA and its improvement after the treatment. Intensity of dyspareunia was evaluated using a visual analog scale (VAS).


Data indicated a significant improvement in VVA dyspareunia (p < 1.86e−22) in breast cancer survivors who had undergone 3 sessions of vaginal fractional CO2 laser treatment. Moreover, VHI scores were significantly higher 30 days post-treatment (T4) (p < 0.0001). 76 % of patients were satisfied or very satisfied with the treatment results. The majority (52 %) of patients were satisfied after a long-term follow-up (mean time 11 months). No adverse events due to fractional CO2 laser treatment occurred.


The treatment with fractionated CO2 laser appeared to be a feasible and effective treatment for VVA dyspareunia in breast cancer survivors with contraindications to hormonal treatments.


Vulvovaginal atrophy Laser Oncological menopause Breast cancer survivors 



We thank DEKA M.E.L.A. S.r.l. for technical support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Annalisa Pieralli
    • 1
    • 2
    Email author
  • Maria Grazia Fallani
    • 1
  • Angelamaria Becorpi
    • 1
  • Claudia Bianchi
    • 1
  • Serena Corioni
    • 1
  • Manuela Longinotti
    • 1
  • Zelinda Tredici
    • 1
  • Secondo Guaschino
    • 1
  1. 1.Section of Gynecology and Obstetrics, Department of Woman and Child HealthCareggi University HospitalFlorenceItaly
  2. 2.FlorenceItaly

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