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Effect of colchicine on polycystic ovary syndrome: an experimental study

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS).

Methods

Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E1), estradiol (E2), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated. Results: cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment.

Conclusion

Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.

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Acknowledgments

This work was done in Experimental Animal Laboratory of Mustafa Kemal University, Hatay, Turkey and supported by Department of Scientific Research Project’s in Mustafa Kemal University.

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Authors and Affiliations

  1. Department of Obstetric and Gynecology, School of Medicine, Mustafa Kemal University, Tayfur Sökmen Kampus, Serinyol, 31000, Hatay, Turkey

    Ilay Ozturk Gozukara & Raziye Keskin Kurt

  2. Department of Pharmacology, School of Medicine, Mustafa Kemal University, Hatay, Turkey

    Neslihan Pınar

  3. Department of Biochemistry, School of Medicine, Mustafa Kemal University, Hatay, Turkey

    Oğuzhan Ozcan

  4. Department of Pathology, School of Medicine, Mustafa Kemal University, Hatay, Turkey

    Tumay Ozgur

  5. Department of Physiology, School of Medicine, Mustafa Kemal University, Hatay, Turkey

    Recep Dokuyucu

  6. Department of Obstetric and Gynecology, School of Medicine, Dumlupınar University, Kutahya, Turkey

    Suna Kabil Kucur

  7. Department of Obstetric and Gynecology, Nenehatun Woman Hospital, Erzurum, Turkey

    Ayşe Nur Aksoy

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  1. Ilay Ozturk Gozukara
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  2. Neslihan Pınar
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Correspondence to Ilay Ozturk Gozukara.

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Gozukara, I.O., Pınar, N., Ozcan, O. et al. Effect of colchicine on polycystic ovary syndrome: an experimental study. Arch Gynecol Obstet 293, 675–680 (2016). https://doi.org/10.1007/s00404-015-3933-5

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  • DOI: https://doi.org/10.1007/s00404-015-3933-5

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