Skip to main content
SpringerLink
Log in

p53 Arg72Pro polymorphism confers the susceptibility to endometriosis among Asian and Caucasian populations

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Findings from studies on the association between the p53 Arg72Pro polymorphism and endometriosis susceptibility have so far been inconsistent. Therefore, we undertook a meta-analysis to clarify the association of p53 Arg72Pro polymorphism with the risk of endometriosis.

Methods

Relevant studies were chosen by searching PubMed, Embase, the Cochrane Library databases, CNKI, Wanfang database, and CBM for articles published before and up to April 30, 2015. Two independent reviewers performed the eligibility evaluation and data extraction. The odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for the overall risk estimate.

Results

Eleven case–control studies involving 1834 endometriosis cases and 2331 controls were included. Pooled data analysis suggested that the p53 72Pro variant is a significant endometriosis risk factors in comparison to the 72Arg variant (Pro vs. Arg: OR = 1.298, 95 % CI 1.082–1.558; Pro/Pro vs. Arg/Arg: OR = 1.751, 95 % CI 1.130–2.711; Pro/Arg vs. Arg/Arg: OR = 1.530, 95 % CI 1.174–1.994), which was strengthened in the dominant model (Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 1.570, 95 % CI = 1.181–2.087). In the stratified analysis by ethnicity and Hardy–Weinberg equilibrium (HWE) in the controls, we found strong associations in Asians and in studies that were consistent with HWE. However, the analyses of the revised American Fertility Society (rAFS) stage and the menopausal status subgroup did not reveal any significant associations.

Conclusion

In conclusion, the p53 Arg72Pro polymorphism was closely related to the risk of endometriosis, especially in Asian populations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Agorastos T, Masouridou S, Lambropoulos AF, Chrisafi S, Miliaras D, Pantazis K, Constantinides TC, Kotsis A, Bontis I (2004) P53 codon 72 polymorphism and correlation with ovarian and endometrial cancer in Greek women. Eur J Cancer Prev 13(4):277–280

    Article  CAS  PubMed  Google Scholar 

  2. Ammendola M, Gloria-Bottini F, Sesti F, Piccione E, Bottini E (2008) Association of p53 codon 72 polymorphism with endometriosis. Fertil Steril 90(2):406–408

    Article  CAS  PubMed  Google Scholar 

  3. Bianco B, Christofolini DM, Brandes A, Lerner TG, Goncalves-Filho RP, Souza AM, Barbosa CP (2011) Analysis of codon 72 polymorphism of the TP53 gene in infertile women with and without endometriosis. Rev Bras Ginecol Obstet 33(1):37–42

    Article  PubMed  Google Scholar 

  4. Brady CA, Attardi LD (2010) p53 at a glance. J Cell Sci 123(Pt 15):2527–2532

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Brosens I, Benagiano G (2011) Endometriosis, a modern syndrome. Indian J Med Res 133:581–593

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Bushe CJ, Bradley AJ, Wildgust HJ, Hodgson RE (2009) Schizophrenia and breast cancer incidence: a systematic review of clinical studies. Schizophr Res 114(1–3):6–16

    Article  PubMed  Google Scholar 

  7. Chang CC, Hsieh YY, Tsai FJ, Tsai CH, Tsai HD, Lin CC (2002) The proline form of p53 codon 72 polymorphism is associated with endometriosis. Fertil Steril 77(1):43–45

    Article  PubMed  Google Scholar 

  8. de Ziegler D, Borghese B, Chapron C (2010) Endometriosis and infertility: pathophysiology and management. Lancet 376(9742):730–738

    Article  PubMed  Google Scholar 

  9. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188

    Article  CAS  PubMed  Google Scholar 

  10. Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33(3):357–365

    Article  CAS  PubMed  Google Scholar 

  11. Dun EC, Taylor RN, Wieser F (2010) Advances in the genetics of endometriosis. Genome Med 2(10):75

    Article  PubMed  PubMed Central  Google Scholar 

  12. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ferrero S, Remorgida V, Maganza C, Venturini PL, Salvatore S, Papaleo E, Candiani M, Leone Roberti Maggiore U (2014) Aromatase and endometriosis: estrogens play a role. Ann N Y Acad Sci 1317:17–23

    Article  CAS  PubMed  Google Scholar 

  14. Gallegos-Arreola MP, Figuera-Villanueva LE, Puebla-Perez AM, Montoya-Fuentes H, Suarez-Rincon AE, Zuniga-Gonzalez GM (2012) Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women. Genet Mol Res 11(2):1401–1408

    Article  CAS  PubMed  Google Scholar 

  15. Gloria-Bottini F, Ammendola M, Saccucci P, Neri A, Magrini A, Bottini E (2015) The effect of ACP, ADA and PTPN22 genetic polymorphisms on the association between p53 codon 72 polymorphism and endometriosis. Arch Gynecol Obstet

  16. He XF, Su J, Zhang Y, Huang X, Liu Y, Ding DP, Wang W, Arparkorn K (2011) Association between the p53 polymorphisms and breast cancer risk: meta-analysis based on case-control study. Breast Cancer Res Treat 130(2):517–529

    Article  CAS  PubMed  Google Scholar 

  17. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558

    Article  PubMed  Google Scholar 

  18. Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460(7259):1132–1135

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF (2004) Detection of genotyping errors by Hardy-Weinberg equilibrium testing. Eur J Hum Genet 12(5):395–399

    Article  CAS  PubMed  Google Scholar 

  20. Hsieh YY, Lin CS (2006) P53 codon 11, 72, and 248 gene polymorphisms in endometriosis. Int J Biol Sci 2(4):188–193

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Huang Y, Zong L, Lin J, Fu Y, Liu Z, Mao T, Zeng J, Wang Y, Zhao X (2013) Association of P53 gene polymorphisms with susceptibility to endometriosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30(3):335–339

    CAS  PubMed  Google Scholar 

  22. Ioannidis JP, Trikalinos TA (2005) Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol 58(6):543–549

    Article  PubMed  Google Scholar 

  23. Jia S, Xu L, Chan Y, Wu X, Yang S, Yu H, Yang H, Luo Y, Tang W (2012) p53 codon 72 polymorphism and endometriosis: a meta-analysis. Arch Gynecol Obstet 285(6):1657–1661

    Article  CAS  PubMed  Google Scholar 

  24. Joerger AC, Fersht AR (2007) Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene 26(15):2226–2242

    Article  CAS  PubMed  Google Scholar 

  25. Lattuada D, Vigano P, Somigliana E, Abbiati A, Candiani M, Di Blasio AM (2004) Analysis of the codon 72 polymorphism of the TP53 gene in patients with endometriosis. Mol Hum Reprod 10(9):651–654

    Article  CAS  PubMed  Google Scholar 

  26. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748

    CAS  PubMed  Google Scholar 

  27. Marte B (2002) Cancer: super p53. Nature 420(6913):279

    Article  CAS  PubMed  Google Scholar 

  28. Mitchell AA, Cutler DJ, Chakravarti A (2003) Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test. Am J Hum Genet 72(3):598–610

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Nikbakht Dastjerdi M, Aboutorabi R, Eslami Farsani B (2013) Association of TP53 gene codon 72 polymorphism with endometriosis risk in Isfahan. Iran J Reprod Med 11(6):473–478

    PubMed  PubMed Central  Google Scholar 

  30. Omori S, Yoshida S, Kennedy SH, Negoro K, Hamana S, Barlow DH, Maruo T (2004) Polymorphism at codon 72 of the p53 gene is not associated with endometriosis in a Japanese population. J Soc Gynecol Investig 11(4):232–236

    Article  CAS  PubMed  Google Scholar 

  31. Piao JM, Kim HN, Song HR, Kweon SS, Choi JS, Yun WJ, Kim YC, Oh IJ, Kim KS, Shin MH (2011) p53 codon 72 polymorphism and the risk of lung cancer in a Korean population. Lung Cancer 73(3):264–267

    Article  PubMed  Google Scholar 

  32. Pim D, Banks L (2004) p53 polymorphic variants at codon 72 exert different effects on cell cycle progression. Int J Cancer 108(2):196–199

    Article  CAS  PubMed  Google Scholar 

  33. Saadat M (2011) Significance of the Hardy-Weinberg equilibrium in genetic association studies. Psychiatry Res 190(1):165

    Article  PubMed  Google Scholar 

  34. Siddique M, Sabapathy K (2006) Trp53-dependent DNA-repair is affected by the codon 72 polymorphism. Oncogene 25(25):3489–3500

    Article  CAS  PubMed  Google Scholar 

  35. Soave I, Caserta D, Wenger JM, Dessole S, Perino A, Marci R (2015) Environment and Endometriosis: a toxic relationship. Eur Rev Med Pharmacol Sci 19(11):1964–1972

    CAS  PubMed  Google Scholar 

  36. Song HR, Kweon SS, Kim HN, Piao JM, Yun WJ, Choi JS, Hwang JE, Yoon JY, Kim HR, Park YK, Kim SH, Choi YD, Shin MH (2011) p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population. Gastric Cancer 14(3):242–248

    Article  PubMed  Google Scholar 

  37. Szczepanska M, Wirstlein P, Holysz H, Skrzypczak J, Jagodzinski PP (2013) The FCRL3 -169T>C polymorphism and the risk of endometriosis-related infertility in a Polish population. Arch Gynecol Obstet 288(4):799–804

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Vietri MT, Molinari AM, Iannella I, Cioffi M, Bontempo P, Ardovino M, Scaffa C, Colacurci N, Cobellis L (2007) Arg72Pro p53 polymorphism in Italian women: no association with endometriosis. Fertil Steril 88(5):1468–1469

    Article  PubMed  Google Scholar 

  39. Ye F, Zhang J, Cheng Q, Shen J, Chen H (2010) p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population. Cancer Lett 287(1):117–121

    Article  CAS  PubMed  Google Scholar 

  40. Ying TH, Tseng CJ, Tsai SJ, Hsieh SC, Lee HZ, Hsieh YH, Bau DT (2011) Association of p53 and CDKN1A genotypes with endometriosis. Anticancer Res 31(12):4301–4306

    CAS  PubMed  Google Scholar 

  41. Zintzaras E (2010) Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis. Eur J Epidemiol 25(8):553–560

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This study was not supported by any kind of funding.

Author information

Authors and Affiliations

  1. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China

    Xianjun Lao

  2. Department of Occupational Health and Environmental Health, School of Public Health at Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China

    Zhiping Chen

  3. Department of Obstetrics and Gynecology, Research Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China

    Aiping Qin

Authors
  1. Xianjun Lao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhiping Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aiping Qin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xianjun Lao.

Ethics declarations

Conflict of interest

The authors declare that they have no financial relationship with the organization that sponsored the research. The authors also state that they have had full control of all primary data and agree to allow the Journal to review their data if requested.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lao, X., Chen, Z. & Qin, A. p53 Arg72Pro polymorphism confers the susceptibility to endometriosis among Asian and Caucasian populations. Arch Gynecol Obstet 293, 1023–1031 (2016). https://doi.org/10.1007/s00404-015-3923-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-015-3923-7

Keywords

Search

Navigation