Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1
Notch signalings are regulated multiple cellular processes during cancer progression. We aimed to investigate the significance and prognostic value of expression of Notch1 and JAG1 in cervical cancer to determine whether they could serve as prognostic predictors.
The expression of Notch1/JAGD1 was investigated by real-time PCR, western blot assay and its association with overall survival of patients was analyzed by statistical analysis.
Notch1 and JAGD1 expression level were significantly elevated in cervical cancer in comparison to normal specimens and other types of Notch receptors and ligands. It is also proved that Notch1 and JAGD1 expression were to be associated with cervical cancer invasion, lymph node metastasis, and FIGO system. In addition, survival analysis proved that elevated Notch1 and JAGD1 expression were associated with poor overall survival of patients (P = 0.01, P = 0.02 log-rank test), respectively.
The present data proved the over-expression of Notch1/JAGD1 and its association with tumor progression in human cervical cancer, which might be a potential valuable biomarker for cervical cancer and further studies need.
KeywordsCervical cancer Notch1 JAG1 Survival rate
Conflict of interest
The authors declare that they have no competing interests.
- 1.American Cancer Society (2012) Cancer facts and figures 2012. American Cancer Society, AtlantaGoogle Scholar
- 3.Doshi WB, Thury PG, Chen R, Fishbein JA, Foley MK (2014) Synergistic interaction between AKT and Notch-1 signaling in cervical cancer: a critical role in tumor cell migration and invasion. Am J Biomed 2(2):200–211Google Scholar
- 4.Yousif NG, Al-Matwari M (2012) Overexpression of Notch-1 induced tamoxifen resistance through down regulation of ESR1 in positive estrogen receptor breast cancer. J Clin Oncol 30(15)Google Scholar
- 15.Han J, Dong RG, Harris MJ, Scholand SF, Miller PW et al (2014) Potential effects of TPX2 in clinicopathologic features, prognosis and metastasis of gastric cancer patients. Am J Biomed 2(1):124–131Google Scholar
- 25.Singer BS, Fishbein JA, Blino SK (2014) Critical role of E6 oncoprotein in cervical cancer: involved in cell proliferation, angiogenesis and apoptosis. Pathophysiol Cell Inj J 2(2):31–41Google Scholar
- 32.Wang DG, Yousif NG, Sadiq AM, Schilling MM, Danielson XJ (2014) Critical role of SEMA5A expression in invasion and metastasis of ovarian cancer cell. Am J Biomed 2(3):292–305Google Scholar