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Evaluation of Lp-PLA2 mass, vitronectin and PAI-1 activity levels in patients with preeclampsia

Archives of Gynecology and Obstetrics volume 292, pages 53–58 (2015)Cite this article

Abstract

Purpose

The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), vitronectin (Vn), Plasminogen activator inhibitor-1 (PAI-1) activity and tissue plasminogen activator (t-PA) levels in early-onset preeclampsia, late-onset preeclampsia and in control pregnant women.

Methods

A total of 79 individuals, 30 early-onsets, and 22 late-onset preeclamptic and 27 control pregnant women were included into the scope of this study. Enzyme-linked immunosorbent assay procedure was used to determine the serum Lp-PLA2 and plasma Vn, t-PA antigen and PAI-1 activity levels. Serum C-reactive protein (CRP) levels were measured immunoturbidimetrically in routine clinical chemistry analyser.

Results

In patients with preeclampsia, Lp-PLA2, PAI-1, t-PA, CRP and blood pressures levels were increased (p = 0.000) and correlated with each other. Vn levels were decreased (p = 0.016) but not correlated with other parameters in preeclamptic patients.

Conclusion

We are of the opinion that increased Lp-PLA2 levels may partially contribute to endothelial dysfunction by the progression of inflammation. In addition, increased complex formation with Vn is likely to bring about the increase of PAI-1 activity in patients with preeclampsia. Moreover, increased t-PA and decreased Vn levels may also be the consequences of compensatory mechanisms against disease progression.

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Acknowledgment

This study was supported by Istanbul University, Scientific Research Projects Unit (Project Number: BYP-20082).

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Biochemistry, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey

    Özlem Balcı Ekmekçi, Hakan Ekmekçi, Zeynep Güngör, M. Sait Toprak, Meltem Korkmaz, Oktay Çalışkan, Mine Kucur, Orkide Donma & Hüseyin Sönmez

  2. Department of Obstetrics and Gynecology, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey

    Abdullah Tüten, Mahmut Öncül & Rıza Madazlı

  3. Seyit ömer Mah. Altı mermer cad. Altı mermer çık. Saray Ap. A Blok. No:2/17 Kocamustafapaşa, Istanbul, Turkey

    Hakan Ekmekçi

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  1. Özlem Balcı Ekmekçi
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Correspondence to Hakan Ekmekçi.

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Balcı Ekmekçi, Ö., Ekmekçi, H., Güngör, Z. et al. Evaluation of Lp-PLA2 mass, vitronectin and PAI-1 activity levels in patients with preeclampsia. Arch Gynecol Obstet 292, 53–58 (2015). https://doi.org/10.1007/s00404-014-3601-1

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  • DOI: https://doi.org/10.1007/s00404-014-3601-1

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