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Congenital HCMV and assisted reproduction: Why not use the chance for primary screening?

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An Erratum to this article was published on 05 October 2015

Abstract

HCMV is the leading cause of congenital infection, with 0.5–0.9 % of infants affected in Europe, and primary maternal infection from the preconceptional phase to the first half of pregnancy bears the highest risk for long-term sequelae-like mental retardation, visual impairment, and progressive sensorineural hearing loss. As compared to couples conceiving spontaneously those under infertility treatment are well accessible to primary HCMV prevention. Since they face higher risk pregnancies this chance should be considered. The concept comprises serological screening for HCMV-IgG, including the partner where appropriate, defining individual risk factors, and counselling on hygiene at the initial assessment of infertility treatment. If seroconversion occurs, the subsequent treatment cycles should be postponed by 6 months. Uncertainties of diagnosis in early pregnancy which may lead to precautious elective termination can be prevented. A newborn at risk of congenital HCMV infection can be identified and scheduled for laboratory and paediatric evaluation within the first 2 weeks of life.

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Acknowledgments

Professor Klaus Hamprecht, Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Germany revised the manuscript thoroughly, and we are grateful for his critical remarks.

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  1. Institute of Immunology, University Hospital Schleswig–Holstein Campus Kiel, Arnold-Heller-Str 3 Haus 17, 24105, Kiel, Germany

    Christiane Kling & Dieter Kabelitz

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Correspondence to Christiane Kling.

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Kling, C., Kabelitz, D. Congenital HCMV and assisted reproduction: Why not use the chance for primary screening?. Arch Gynecol Obstet 291, 1205–1211 (2015). https://doi.org/10.1007/s00404-014-3583-z

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