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Follicle-stimulating hormone receptor gene polymorphisms in women with endometriosis

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objectives

The purpose of this study was to evaluate the influence of the follicle-stimulating hormone (FSH) receptor poymorphisms Asn680Ser and Thr307Ala on endometriosis in Turkish women.

Methods

Polymorphic analysis of the FSH receptor gene was performed in 100 patients with endometriosis and 100 controls. Genomic DNA was obtained from peripheral blood leukocytes and polymorphisms were investigated using restriction fragment length polymorphism analysis.

Results

There were no significant differences in genotype frequencies of FSH receptor gene between endometriosis patients and controls. When the patients were divided into two groups according to disease severity, we found that the patients with the SS (680 Ser/Ser) or AA (307 Ala/Ala) genotype were less likely to develop stage 3–4 endometriosis compared to the stage 1–2 endometriosis group (P = 0.004; OR: 0.177, 95 % CI 0.055–0.568 and P = 0.040; OR: 0.240, 95 % CI 0.061–0.938; respectively).

Conclusions

The distributions of FSHR polymorphisms may not have an effect on endometriosis development but they are associated with the severity of the disease. The polymorphisms encoding SS at the position 680 and AA at the position 307 and the patients with the genotype that included alanine or serine were less likely to develop stage 3–4 endometriosis compared to the stage 1–2 endometriosis group.

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Acknowledgments

This study was supported by Selcuk University Scientific Projects fund.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Selçuk University Medicine Faculty, Selçuklu, Konya, Turkey

    Ozlem Secilmis Kerimoglu, Setenay Arzu Yılmaz, Aybike Pekin, Feyzanur İncesu & Cetin Celik

  2. Department of Medical Genetics, Selçuk University Medicine Faculty, Selçuklu, Konya, Turkey

    Suleyman Nergiz & Hasan Acar

  3. Department of Obstetrics and Gynecology, Akdeniz University Medicine Faculty, Antalya, Turkey

    Nasuh Utku Dogan

Authors
  1. Ozlem Secilmis Kerimoglu
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  2. Setenay Arzu Yılmaz
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  5. Feyzanur İncesu
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  6. Nasuh Utku Dogan
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  8. Cetin Celik
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Correspondence to Ozlem Secilmis Kerimoglu.

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Kerimoglu, O.S., Yılmaz, S.A., Pekin, A. et al. Follicle-stimulating hormone receptor gene polymorphisms in women with endometriosis. Arch Gynecol Obstet 291, 1411–1416 (2015). https://doi.org/10.1007/s00404-014-3562-4

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  • DOI: https://doi.org/10.1007/s00404-014-3562-4

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