Skip to main content

Is there an association between liver type fatty acid binding protein and severity of preeclampsia?



The aim of this study was to estimate the level of liver fatty acid binding protein (LFABP) in women with preeclampsia.


A case–control study was conducted in 90 pregnant women who were divided into the following three groups: normal pregnancy (n = 30), mild–moderate preeclampsia (n = 30), and severe preeclampsia (n = 30). Maternal blood samples were obtained during an antenatal clinic visit in normal pregnant women, and at the time of diagnosis in women with preeclampsia. Serum LFABP levels were measured by the quantitative sandwich enzyme immunoassay technique.


Serum LFABP level was significantly higher in severe and mild–moderate preeclampsia groups than normal pregnancy group (1,709.90 ± 94.82, 1,614.93 ± 118.22, and 1,532.36 ± 140.98 pg/ml, respectively; p < 0.001). In multivariate analysis, the severity of preeclampsia was correlated with LFABP level [unadjusted odds ratio (95 % confidence interval), 1.008 (1.003–1.012), p < 0.001 and LDH 1.063 (1.029–1.099), p < 0.001].


Maternal serum LFABP level appears to be correlated with the severity of the preeclampsia and can be used to confirm the diagnosis.

This is a preview of subscription content, access via your institution.


  1. El Beltagy NS, El Deen Sadek SS, Zidan MA et al (2011) Can serum free fatty acids assessment predict severe preeclampsia? Alex J Med 47:277–281

    Article  Google Scholar 

  2. Can M, Sancar E, Harma M, Guven B, Mungan G, Acikgoz S (2011) Inflammatory markers in preeclamptic patients. Clin Chem Lab Med 49:1469–1472

    Article  CAS  PubMed  Google Scholar 

  3. Chelbi ST, Veitia RA, Vaiman D (2013) Why preeclampsia still exists? Med Hypotheses 81:259–263

    Article  PubMed  Google Scholar 

  4. Yalcin S, Ulas T, Eren MA et al (2013) Relationship between oxidative stress parameters and cystatin C levels in patients with severe preeclampsia. Medicina (Kaunas) 49:118–123

    Google Scholar 

  5. Engin-Ustün Y, Ustün Y, Karabulut AB, Ozkaplan E, Meydanli MM, Kafkasli A (2007) Serum amyloid A levels are increased in pre-eclampsia. Gynecol Obstet Invest 64(2):117–120

    Article  PubMed  Google Scholar 

  6. Toy H, Camuzcuoglu H, Arioz DT et al (2009) Serum prolidase activity and oxidative stress markers in pregnancies with intrauterine growth restricted infants. J Obstet Gynaecol Res 35:1047–1053

    Article  CAS  PubMed  Google Scholar 

  7. Villa PM, Laivuori H, Kajantie E et al (2009) Free fatty acid profiles in preeclampsia. Prostaglandins Leukot Essent Fatty Acids 81:17–21

    Article  CAS  PubMed  Google Scholar 

  8. Scifres CM, Catov JM, Simhan H (2012) Maternal serum fatty acid binding protein 4 (FABP4) and the development of preeclampsia. J Clin Endocrinol Metab 97:E349–E356

    Article  CAS  PubMed  Google Scholar 

  9. Chaemsaithong P, Chaiworapongsa T, Romero R et al (2014) Maternal plasma soluble TRAIL is decreased in preeclampsia. J Matern Fetal Neonatal Med 27:217–227

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Atshaves BP, Martin GG, Hostetler HA et al (2010) Liver fatty acid binding protein and obesity. J Nutr Biochem 21:1015–1032

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. De Gerónimo E, Hagan RM, Wilton DC et al (2010) Natural ligand binding and transfer from liver fatty acid binding protein (LFABP) to membranes. Biochim Biophys Acta 1801:1082–1089

    Article  PubMed  Google Scholar 

  12. Lehnen H, Mosblech N, Reineke T et al (2013) Prenatal clinical assessment of sFlt-1 (Soluble fms-like tyrosine kinase-1)/PlGF (Placental growth factor) ratio as a diagnostic tool for preeclampsia, pregnancy-induced hypertension, and proteinuria. Geburtshilfe Frauenheilkd 73:440–445

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Alexander GR, Himes JH, Kaufman RB et al (1996) A United States national reference for fetal growth. Obstet Gynecol 87:163–168

    Article  CAS  PubMed  Google Scholar 

  14. ACOG Committee on Obstetric Practice (2002) ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Int J Gynaecol Obstet 77:67–75 (Number 33, January 2002. American College of Obstetricians and Gynecologists)

    Article  Google Scholar 

  15. Sasaki H, Kamijo-Ikemori A, Sugaya T et al (2009) Urinary fatty acids and liver-type fatty acid binding protein in diabetic nephropathy. Nephron Clin Pract 112:c148–c156

    Article  CAS  PubMed  Google Scholar 

  16. Ozenirler S, Erkan G, Gulbahar O et al (2011) Serum levels of advanced oxidation protein products, malonyldialdehyde, and total radical trapping antioxidant parameter in patients with chronic hepatitis C. Turk J Gastroenterol 22:47–53

    PubMed  Google Scholar 

  17. Basak S, Das MK, Duttaroy AK (2013) Fatty acid-induced angiogenesis in first trimester placental trophoblast cells: possible roles of cellular fatty acid-binding proteins. Life Sci 93:755–762

    Article  CAS  PubMed  Google Scholar 

  18. Foucaud L, Grillasca J, Niot I et al (1999) Output of liver fatty acid-binding protein (L-FABP) in bile. Biochim Biophys Acta 1436:593–599

    Article  CAS  PubMed  Google Scholar 

  19. Thompson J, Ory J, Reese-Wagoner A et al (1999) The liver fatty acid binding protein–comparison of cavity properties of intracellular lipid-binding proteins. Mol Cell Biochem 192:9–16

    Article  CAS  PubMed  Google Scholar 

  20. Thompson J, Reese-Wagoner A, Banaszak L (1999) Liver fatty acid binding protein: species variation and the accommodation of different ligands. Biochim Biophys Acta 23:117–130

    Article  Google Scholar 

  21. Lagakos WS, Guan X, Ho SY et al (2013) Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol. J Biol Chem 288:19805–19815

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Akbal E, Koklu S, Cakal B, Gunes F, Basar O, Tuna Y, Senes M (2013) Liver fatty acid-binding protein is a diagnostic marker to detect liver injury due to chronic hepatitis C infection. Arch Med Res 44:34–38

    Article  CAS  Google Scholar 

  23. Robinson NJ, Minchell LJ, Myers JE et al (2009) A potential role for free fatty acids in the pathogenesis of preeclampsia. J Hypertens 27:1293–1302

    Article  CAS  PubMed  Google Scholar 

  24. Shangguan X, Liu F, Wang H et al (2009) Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Clin Chim Acta 407:58–61

    Article  CAS  PubMed  Google Scholar 

  25. Zar T, Kohn OF, Kaplan AA (2011) Fractional excretion of urea in pre-eclampsia: a clinical observation. Iran J Kidney Dis 5:398–403

    PubMed  Google Scholar 

Download references

Conflict of interest

The authors have no conflict of interest.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ozlem Uzunlar.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Uzunlar, O., Engin-Ustun, Y., Ozyer, S. et al. Is there an association between liver type fatty acid binding protein and severity of preeclampsia?. Arch Gynecol Obstet 291, 1069–1074 (2015).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • Severe preeclampsia
  • Mild preeclampsia
  • Diagnosis of preeclampsia
  • Serum lactate dehydrogenase
  • Serum protein
  • Serum albumin
  • Liver fatty acid binding protein